Dapoxetine for Premature Ejaculation
Dapoxetine hydrochloride,
was originally an antidepressant drug but researchers discovered it had an
interesting side-effect.
JnJ company ALZA Corporation announced that it
has submitted a new drug application to the U.S. Food and Drug
Administration (FDA) for dapoxetine hydrochloride (S-(+)-N,N-dimethyl-a-[2-(naphthalenyloxy)ethyl]
benzenemethanamine hydrochloride, structure of dapoxetine without HCl shown
on the right) a new treatment for
premature ejaculation (PE). Premature ejaculation is the most common male
sexual dysfunction, affecting as many as one-third of men worldwide at some
time in their lives.
"Premature ejaculation is a frequent and distinct medical condition that can
severely impact quality of life, affecting the physical and emotional
well-being of patients and their partners," says James H. Barada, M.D.,
urologist at the Center for Male Sexual Health, Albany, NY, and board member
of the Sexual Medicine Society of North America (SMSNA).
If approved by the FDA, dapoxetine hydrochloride would be the first
prescription treatment designed specifically to treat PE and will be
marketed in the U.S. by Ortho-McNeil Pharmaceutical, Inc.
ALZA Corporation, headquartered in Mountain View, California, is leading the
next generation of drug delivery, with the world's broadest array of
technology platforms, including oral, transdermal, implantable, and
liposomal technologies. More than 30 products marketed in over 80 countries
worldwide now incorporate ALZA's drug delivery technologies.
Dapoxetine (3D structure of dapoxetine shown left) was originally an antidepressant and one of the side effects of
several antidepressants is retarded ejaculation (an inability to reach
orgasm), inability to sustain an erection and/or impotence. It was
pharmacologist Karl Thor who spotted the repositioning potential of
Dapoxetine and suggested its indication for PE. Assuming there are now last
minute regulatory problems, it is assumed that the drug will be granted a
licence for this indication in the near future. Numerous drug companies have
seen the potential benefits of reprofiling old drugs rather than starting
from scratch with each new disease or disorder.
Since this article was written regulatory approval for dapoxetine hydrochloride has been refused, so read on to discover how to cure premature ejaculation, permanently.
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