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	<title>Sciencebase Science Blog &#187; spectroscopy</title>
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	<link>http://www.sciencebase.com/science-blog</link>
	<description>Science Blog from Freelance Science Writer David Bradley</description>
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		<title>Whatever Happened to SARS?</title>
		<link>http://www.sciencebase.com/science-blog/whatever-happened-to-sars.html</link>
		<comments>http://www.sciencebase.com/science-blog/whatever-happened-to-sars.html#comments</comments>
		<pubDate>Fri, 20 Feb 2009 13:00:16 +0000</pubDate>
		<dc:creator>David Bradley</dc:creator>
				<category><![CDATA[Science]]></category>
		<category><![CDATA[spectroscopy]]></category>
		<category><![CDATA[disease]]></category>
		<category><![CDATA[SARS]]></category>
		<category><![CDATA[virus]]></category>

		<guid isPermaLink="false">http://www.sciencebase.com/science-blog/?p=3657</guid>
		<description><![CDATA[In 2004, I did some reportage for the Royal Society from their meeting on emerging viral infections. The meeting was held just after the worldwide SARS outbreak that threw nations into chaos and had the more susceptible parts of the media hyping the end of the world. Of course, SARS, an emerging pathogen, was lethal [...]<p><a href="http://www.sciencebase.com/science-blog/whatever-happened-to-sars.html">Whatever Happened to SARS?</a> is a post from: <a href="http://www.sciencebase.com/science-blog">Sciencebase Science Blog</a></p>
]]></description>
			<content:encoded><![CDATA[<p><a href="http://www.flickr.com/photos/dearterisa/215409413/" rel="nofollow"><img style="float:left;width:120px;padding-right:4px;padding-top:5px;" src="http://www.sciencebase.com/images/sars-epidemic.jpg" alt="sars-epidemic" title="sars-epidemic" /></a>In 2004, I did some reportage for the Royal Society from their meeting on <a href="http://www.sciencebase.com/viral_infection_emerging.html">emerging viral infections</a>. The meeting was held just after the worldwide SARS outbreak that threw nations into chaos and had the more susceptible parts of the media hyping the end of the world. Of course, SARS, an emerging pathogen, was lethal and had devastating effects on thousands of people.</p>
<p>Ultimately, the first SARS outbreak was controlled, and a subsequent epidemic is yet to emerge. Severe acute respiratory syndrome, the disease caused by a highly infectious RNA coronavirus, remains in waiting. SARS is still an issue, it can, when required, undergo frequent mutations, which adds unpredictability to a future outbreak. There is no vaccine, assay, or treatment yet. Health officials can only resort to isolation and quarantine to control its spread.</p>
<p>In the meantime, scare stories surrounding the potential for avian influenza H5N1 have filled many column inches and web estate since that strain was first identified. We are, obviously, yet to succumb to an epidemic of global proportions of an evolved strain of H5N1 that could be transmitted person to person.</p>
<p>&#8220;At the peak of the worldwide SARS epidemic, apprehension arose out of partially disclosed, if not concealed, information on the current status,&#8221; says Yi-Chun Lin, at the Central Police University, in Taoyuan, Taiwan ROC. This he says led to many foreign companies to withdraw their business from Taiwan or move their bases elsewhere. At the time of the crisis, normal trading, investment and travel were suspended or came to a standstill. Some regions are yet to make a complete recovery from SARS and the advent of H5N1 in South Asia as well as the potential for the emergence of yet another virus or other pathogen has many investors wary of the region.</p>
<p>Lin suggests that proposals to be acted on in an emergency to help contain an emerging crisis, without obfuscation, ought to be put in place. This would allow foreign investors to undertake risk control assessment for this part of the world, ignore the scare-mongering, and be assured that whatever the next disease to emerge may be it will not have the shocking and devastating effects it otherwise would.</p>
<p>&#8220;<span style="position:relative;color:white;width:200px;background:#05024F;border-width: 0px 0px 0px 0px;border-style: dotted;border-color: --;filter:alpha(opacity=25);-moz-opacity:.25;opacity:.25;float:right;padding: 0.2em; margin: 1em;font-family:Verdana,Arial, Helvetica,Georgia;font-size: 24px;line-height:26px; text-align: right;"><span style="filter:alpha(opacity=75);-moz-opacity:.75;opacity:.75;">SARS </span><b> </b>dramatically <br><b></b>illustrated <br><b>the </b>wide-ranging <br><b>impact that </b>a <br><b>new </b>disease <br><b></b>can<span style="filter:alpha(opacity=90);-moz-opacity:.90;opacity:.90;"> have</span></span>SARS dramatically illustrated the wide-ranging impact that a new disease can have in a closely interconnected and highly mobile world,&#8221; Lin says, &#8220;The public anxiety it incited spread faster than the virus, causing social unease and economic losses.&#8221; The suddenness of the outbreak provided a critical test of medical systems, infection control policies, and tested many national disease response and crisis management abilities.</p>
<p>In a subsequent disease crisis, human lives will be at risk and economic stability [for what that is worth at the moment!] thrown into jeopardy. &#8220;It is thus important to learn from experience and enhance preparedness for future,&#8221; adds Lin.</p>
<p><img style="float:left;padding-right:4px;padding-top:5px;" src="http://www.sciencebase.com/images/research-blogging-icon.png" alt="Research Blogging Icon" /><span class="Z3988" title="ctx_ver=Z39.88-2004&#038;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&#038;rft.jtitle=Int.+J.+Risk+Assess.+Manage.&#038;rft_id=info%3Adoi%2F&#038;rfr_id=info%3Asid%2Fresearchblogging.org&#038;rft.atitle=Impact+of+the+spread+of+infectious+disease+on+economic+development%3A+a+study+in+risk+management&#038;rft.issn=&#038;rft.date=2009&#038;rft.volume=11&#038;rft.issue=3%2F4&#038;rft.spage=209&#038;rft.epage=218&#038;rft.artnum=&#038;rft.au=Yi-Chun+Lin&#038;rfe_dat=bpr3.included=1;bpr3.tags=Biology">Yi-Chun Lin (2009). Impact of the spread of infectious disease on economic development: a study in risk management <span style="font-style: italic;">Int. J. Risk Assess. Manage., 11</span> (3/4), 209-218</span></p>
<div id="crp_related"><h3>Related Posts:</h3><ul><li><a href="http://www.sciencebase.com/science-blog/sars-bacterium.html" rel="bookmark">The SARS bacterium?</a></li><li><a href="http://www.sciencebase.com/science-blog/swine-flu-update.html" rel="bookmark">Swine Flu Update</a></li><li><a href="http://www.sciencebase.com/science-blog/needle-free-bird-flu-vaccine.html" rel="bookmark">Needle free bird flu vaccine</a></li></ul></div><p><a href="http://www.sciencebase.com/science-blog/whatever-happened-to-sars.html">Whatever Happened to SARS?</a> is a post from: <a href="http://www.sciencebase.com/science-blog">Sciencebase Science Blog</a></p>
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		<title>Alchemy, Spectroscopy, and the Hash</title>
		<link>http://www.sciencebase.com/science-blog/alchemy-spectroscopy-and-the-hash.html</link>
		<comments>http://www.sciencebase.com/science-blog/alchemy-spectroscopy-and-the-hash.html#comments</comments>
		<pubDate>Wed, 18 Feb 2009 13:00:04 +0000</pubDate>
		<dc:creator>David Bradley</dc:creator>
				<category><![CDATA[Science]]></category>
		<category><![CDATA[spectroscopy]]></category>
		<category><![CDATA[Astronomy]]></category>
		<category><![CDATA[chemistry]]></category>

		<guid isPermaLink="false">http://www.sciencebase.com/science-blog/?p=3666</guid>
		<description><![CDATA[In the latest ezines from SpectroscopyNOW:
Magnetic drug delivery for Alzheimer&#8217;s disease &#8211; Tiny pieces of magnetite incorporated into chitosan microparticles could act as efficient drug-delivery agents for the Alzheimer&#8217;s drug tacrine. Tacrine has notoriously low oral bioavailability and unclear efficacy but this delivery approach boosts uptake.
Contrasting tumours &#8211; US scientists have successfully predicted the outcome [...]<p><a href="http://www.sciencebase.com/science-blog/alchemy-spectroscopy-and-the-hash.html">Alchemy, Spectroscopy, and the Hash</a> is a post from: <a href="http://www.sciencebase.com/science-blog">Sciencebase Science Blog</a></p>
]]></description>
			<content:encoded><![CDATA[<p><img style="float:left;width:120px;padding-right:4px;padding-top:5px;" src="http://www.sciencebase.com/images/sn41b_a_drug_delivery.jpg" alt="magnetic drug delivery" title="magnetic drug delivery" />In the latest ezines from SpectroscopyNOW:</p>
<p><a href="http://www.spectroscopynow.com/coi/cda/detail.cda?id=20559&#038;type=Feature&#038;chId=3&#038;page=1">Magnetic drug delivery for Alzheimer&#8217;s disease</a> &#8211; Tiny pieces of magnetite incorporated into chitosan microparticles could act as efficient drug-delivery agents for the Alzheimer&#8217;s drug tacrine. Tacrine has notoriously low oral bioavailability and unclear efficacy but this delivery approach boosts uptake.</p>
<p><a href="http://www.spectroscopynow.com/coi/cda/detail.cda?id=20554&#038;type=Feature&#038;chId=3&#038;page=1">Contrasting tumours</a> &#8211; US scientists have successfully predicted the outcome on breast tumours in a pre-clinical study of a so-called nano drug. Their research could help determine which patients will respond best to these and other drugs.</p>
<p><a href="http://www.spectroscopynow.com/coi/cda/detail.cda?id=20550&#038;type=Feature&#038;chId=3&#038;page=1">Long-distance protein</a> &#8211; The behaviour of dynein, a relatively little-studied protein found in muscle has been characterised using fluorescent markers and electron microscopy, paving the way for X-ray diffraction and NMR spectroscopy studies.</p>
<p><a href="http://www.spectroscopynow.com/coi/cda/detail.cda?id=20551&#038;type=Feature&#038;chId=3&#038;page=1">Farming phosphorus</a> &#8211; Phosphorus NMR can help distinguish between the nature of organic and non-organic farming and provide clues about how phosphorus from both sources affects waterways and coasts.</p>
<p>Under February&#8217;s Spotlight over on Intute I reported on:</p>
<p><a href="http://www.intute.ac.uk/sciences/spotlight/issue69/ocean_going_stalks%20.html">Ocean-going stalks fight global warming</a> &#8211; Burying crop residues at sea may help reduce global warming, according to researchers in the USA. They suggest that transporting millions of tonnes of bailed up cornstalks, wheat straw, and other crop residues from farms, and burying it in the deep ocean.</p>
<p><a href="http://www.intute.ac.uk/sciences/spotlight/issue69/testing_times_chameleon_ch.html">Testing times for chameleon chromium</a> &#8211; A new standard for chemical testing has been developed for a carcinogenic chromium salt. The hexavalent chromium ion was at the heart of the pollution controversy on which the movie Erin Brokovich was based.</p>
<p><a href="http://www.intute.ac.uk/sciences/spotlight/issue69/Musing_on_supermassive_black_h.html">Musing on supermassive black holes</a> &#8211; New observations from a collection of powerful telescopes have allowed astronomers from Germany and the US to settle a paradox regarding the behaviour of merging <a href="http://www.smoothfitness.com/ellipticals-machines">elliptical</a> galaxies. The team has revealed evidence that the largest, , most massive galaxies in the universe and the supermassive black holes at their cores grow together rather than one leading to the other, which explains the &#8220;fluffy&#8221; nature of their central regions.</p>
<p><a href="http://www.chemweb.com/content/alchemist/alchemist_20090211.html">Alchemist news this week</a> &#8211; We hear how tubular soot, better known as carbon nanotubes, might displace costly platinum in future fuel cells and so herald a new era in power supply. In physical chemistry new insights could explain why molten glass solidifies but retains the structure of a liquid and in biochemistry a new approach to producing glycoproteins could bring some regularity to biomedical research into these substances.</p>
<p>Also, under the Alchemist&#8217;s gaze: In troubled times, airport security is high on the agenda and a new detector system for spotting secreted liquid explosives is emerging from the prototype stage. Finally, carbon dioxide is not all bad, research into its effects on wound healing has led to a significant prize for British scientists.</p>
<p>Speaking of alchemists watch out for my &#8220;Science and Islam&#8221; with embedded video this Friday, you can call me Al.</p>
<p>Oh, the hash? Well&#8230;strongest link would have to be <a href="http://search.twitter.com/search?q=%23science">#science</a>, but I just want to reference The Pogues in a very abstruse way.</p>
<div id="crp_related"><h3>Related Posts:</h3><ul><li><a href="http://www.sciencebase.com/science-blog/bond-q-and-controlled-cleavage.html" rel="bookmark">Bond, Q, and Controlled Cleavage</a></li><li><a href="http://www.sciencebase.com/science-blog/flu-structure-extended-mp3s-and-magnetic-minestrone.html" rel="bookmark">Flu Structure, Mp3s, and Magnetic Minestrone</a></li><li><a href="http://www.sciencebase.com/science-blog/light-trials-balls.html" rel="bookmark">Light, Trials, Balls</a></li></ul></div><p><a href="http://www.sciencebase.com/science-blog/alchemy-spectroscopy-and-the-hash.html">Alchemy, Spectroscopy, and the Hash</a> is a post from: <a href="http://www.sciencebase.com/science-blog">Sciencebase Science Blog</a></p>
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		<title>Rhodiola rosea</title>
		<link>http://www.sciencebase.com/science-blog/rhodiola-rosea.html</link>
		<comments>http://www.sciencebase.com/science-blog/rhodiola-rosea.html#comments</comments>
		<pubDate>Wed, 22 Oct 2008 13:00:54 +0000</pubDate>
		<dc:creator>David Bradley</dc:creator>
				<category><![CDATA[Chemspy]]></category>
		<category><![CDATA[Geek]]></category>
		<category><![CDATA[Science]]></category>
		<category><![CDATA[spectroscopy]]></category>
		<category><![CDATA[Health]]></category>
		<category><![CDATA[pseudoscience]]></category>

		<guid isPermaLink="false">http://www.sciencebase.com/science-blog/?p=2089</guid>
		<description><![CDATA[The marketing hype surrounding Rhodiola rosea would suggest that anyone taking it would be cured of almost any ailment and have renewed vitality. It may have some benefits, as yet unproven, but the idea that it could allow you to live long and prosper? Well, there are no peer-reviewed scientific research papers to support such [...]<p><a href="http://www.sciencebase.com/science-blog/rhodiola-rosea.html">Rhodiola rosea</a> is a post from: <a href="http://www.sciencebase.com/science-blog">Sciencebase Science Blog</a></p>
]]></description>
			<content:encoded><![CDATA[<p><img style="float: left; width: 120px; padding-right: 4px; padding-top: 5px;" src="http://www.sciencebase.com/images/rhodiola-rosea.jpg" alt="rhodiola-rosea">The marketing hype surrounding <em>Rhodiola rosea</em> would suggest that anyone taking it would be cured of almost any ailment and have renewed vitality. It may have some benefits, as yet unproven, but the idea that it could allow you to live long and prosper? Well, there are no peer-reviewed scientific research papers to support such claims.</p>
<p>
<div style="float: right; padding-top: 5px;"> <script type="text/javascript"><!-- google_ad_client = "pub-3573213190048175"; /* 300x250, created 19/03/08 */ google_ad_slot = "1462111821"; google_ad_width = 300; google_ad_height = 250; //--> </script><br /> <script type="text/javascript" src="http://pagead2.googlesyndication.com/pagead/show_ads.js"> </script> </div>
<p><em>R rosea</em> (aka  golden root, roseroot, hóng jǐng tiān in <a href="http://www.sciencebase.com/science-blog/traditional-chinese-medicine-2.html">TCM</a>) is a member of the Crassulaceae family and grows across the Arctic, the mountains of Central Asia, the Rockies, the Alps, the Pyrenees, the Carpathian Mountains, Scandinavia, Iceland, Great Britain and Ireland. According to some herbalists it could be an elixir for life.</p>
<p>The Wikipedia entry for <em>R rosea</em> says it may be effective for improving mood and alleviating depression and early stage studies on people have shown some efficacy in improving physical and mental performance, alleviating fatigue, and reducing high-altitude sickness. A possible mode of action involves what the entry describes as, &#8220;optimizing serotonin and dopamine levels&#8221;. This apparently  happens by inhibition of the enzyme monoamine oxidase, which supposedly ties in with an effect on endorphins, the body&#8217;s natural opiates. However, there is no scientific evidence for this activity and it would seem to be pure speculation.</p>
<p>According to a press release I received recently, <em>R rosea</em> is a remarkable story. It is the story of how a traditional herbal remedy from Sweden became the force behind Soviet Olympic athletes and cosmonauts. The Swedish Herbal Institute has even done what the email claims is &#8220;hard&#8221; research, unusually for a herbal product, in the form of double-blind, placebo-controlled, randomized clinical trials.</p>
<p>It&#8217;s worth noting that the SHI, which seems to be the only place publishing any research on this, actually holds a trademark on an extract of <em>R rosea</em>, referring to it as Arctic Root (SHR-5). So, one might say that their research is not without designs on the herbal remedies market. It is also sold in the US as ADAPT 232.</p>
<p>The press release highlights a previously published article that claims that, &#8220;the roots appear to aid the brain by alertness and energy, without any trace of stimulants such as caffeine.&#8221;</p>
<p>Isn&#8217;t that a contradiction in terms? If the root stimulates the brain, then surely by definition it is a stimulant?</p>
<p>I asked the author of the press release, Linda Todten of publicity company TMC Communications, to explain exactly what the description was intended to convey, this is what she had to say:</p>
<p><em>As you know, the trend is for &#8220;energy drinks&#8221; that combine large amounts of caffeine, or caffeine containing plants such as Guarana, along with high amounts of carbs for a big &#8220;energy boost.&#8221; The studies that the Swedes and Russians have done over the years have shown how this category of plant, the Adaptogen, can actually bring the body back to its full energy level without being over stimulated as happens with caffeine. Plus, the extract SHR-5 has been shown to have a very solid mental acuity boost via double-blind, placebo controlled studies in students or night shift physicians and others.</em></p>
<p>But, any product with a physiological effect cannot be without some side-effects; no herbal extract could be that specific at the molecular level. </p>
<p>Indeed, the plant root contains a variety of natural products including rosavin, rosarin, rosin and salidroside (and sometimes p-tyrosol, rhodioniside, rhodiolin and rosiridin), which are all described as active ingredients of <em>R rosea</em>. These compounds are polyphenols, they may have <a href="http://www.sciencebase.com/science-blog/nutraceutical-nonsense.html">some antioxidant activity</a> but have no proven health benefits in humans.</p>
<p><em>R rosea</em> products are marketed in the USA and elsewhere. Todten had this suggestion: &#8220;Think about the fact that this one product (Arctic Root brand) has sold over 400 million doses. Not many dietary supplements can claim that. That says, to me, that people must like the way it works to reduce stress or energize,&#8221; she told me. &#8220;People are not sheep, and they wouldn&#8217;t make a product a best seller in Europe over ten years with hundreds of millions taken if it didn&#8217;t do something that they liked!&#8221;</p>
<p>Well, it suggests to me nothing more than effective marketing. When the medical literature provides results of large-scale, randomised, double-blind, placebo-controlled clinical trials of <em>R rosea</em> other than those being carried out by people selling the stuff please let me know.</p>
<p>I realise this last statement may seem contradictory after all, pharmaceutical companies carry out and publish their own trials on their products&#8230;but the difference is that regulatory bodies don&#8217;t insist on seeing the results and limiting unwarranted allusions to unproven health benefits.</p>
<p>Comments are now closed on this old post as we&#8217;ve passed the 100 comment point.</p>
<div id="crp_related"><h3>Related Posts:</h3><ul><li><a href="http://www.sciencebase.com/science-blog/how-alternative-medicine-fails-us.html" rel="bookmark">How Alternative Medicine Fails Us</a></li><li><a href="http://www.sciencebase.com/science-blog/how-does-herbal-medicine-work" rel="bookmark">How Does Herbal Medicine Work</a></li><li><a href="http://www.sciencebase.com/science-blog/unnatural-approach-to-diabetes.html" rel="bookmark">Unnatural Approach to Diabetes</a></li></ul></div><p><a href="http://www.sciencebase.com/science-blog/rhodiola-rosea.html">Rhodiola rosea</a> is a post from: <a href="http://www.sciencebase.com/science-blog">Sciencebase Science Blog</a></p>
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		<title>How to Discover Our Universe</title>
		<link>http://www.sciencebase.com/science-blog/discover-our-universe.html</link>
		<comments>http://www.sciencebase.com/science-blog/discover-our-universe.html#comments</comments>
		<pubDate>Wed, 20 Aug 2008 12:00:37 +0000</pubDate>
		<dc:creator>David Bradley</dc:creator>
				<category><![CDATA[Science]]></category>
		<category><![CDATA[spectroscopy]]></category>
		<category><![CDATA[cosmology]]></category>

		<guid isPermaLink="false">http://www.sciencebase.com/science-blog/?p=1817</guid>
		<description><![CDATA[Apparently, scientific thought needs rekindling, seemingly it has run out of kindle and needs a new flame if it is to burn brighter. In steps Terence Witt with the concept of null physics. Witt has now self-published a hefty tome by the name of Our Undiscovered Universe.
According to the press blurb that came with my [...]<p><a href="http://www.sciencebase.com/science-blog/discover-our-universe.html">How to Discover Our Universe</a> is a post from: <a href="http://www.sciencebase.com/science-blog">Sciencebase Science Blog</a></p>
]]></description>
			<content:encoded><![CDATA[<p><img style="float:left;padding-right:4px;padding-top:5px;" src="http://www.sciencebase.com/images/our-undiscovered-universe.jpg" alt="Our Undiscovered Universe" />Apparently, scientific thought needs rekindling, seemingly it has run out of kindle and needs a new flame if it is to burn brighter. In steps Terence Witt with the concept of null physics. Witt has now self-published a hefty tome by the name of <a href="http://www.ourundiscovereduniverse.com" rel="nofollow">Our Undiscovered Universe</a>.</p>
<p>According to the press blurb that came with my review copy of the book, he&#8217;s a visiting scientist at Florida Institute of Technology. Now, I can find FIT on the web, but I cannot find Witt at FIT. Anyway, he puts forward an intriguing, if not entirely original, idea that modern physics requires a paradigm shift back to common sense thinking and a logical reconnection between observation and theory.</p>
<p>There is, Witt says, a disconnect between the two in our current Big Bang theory of the origins of the universe. In <em>Our Undiscovered Universe</em>, Witt puts forward the hypothesis that the universe is static and not expanding, and rouses various equations to explain away the red shift of distant cosmic objects and concepts such as dark matter and dark energy. Likewise there is a disconnect between the purportedly irrational quantum world and the reality we observe.</p>
<p>Perhaps there are almost as many loopholes in modern physics as there are wormholes and maybe it is possible to tangle up any scientific model with enough string to fill a universe. But, Witt&#8217;s is too comfortable a conclusion, that the universe does not rely on any unknowable precursors in the untestable past and will not grow old, collapse or die, but is an unimaginably large cosmic engine. Moreover, his null hypothesis suggests that &#8220;our universe actually is, the only thing it could possibly be: the internal structure of nothingness.&#8221;</p>
<p>So, you might ask, what is Witt&#8217;s evidence for this concept? He explains that evidence of the Null Axiom is everywhere:</p>
<ul>
<li>Matter and antimatter are always created in equal, yet opposite amounts whose electrical sum is zero
<li>Positive and negative electric fields sum to a neutral universe with zero net electrical charge
<li>Energy is conserved in all interactions; the magnitude of the universe&#8217;s energy has zero change
<li>Space is a collection of points, little bits of nothingness itself, which embodies a geometric zero &#8211; Null
<li>Charge must be conserved in particle interactions; the sum of the difference between charges is zero
<li>Momentum is conserved, so the universe&#8217;s net momentum remains constant at zero
</ul>
<p>I put a few questions to Witt on behalf of Sciencebase readers. First off, I asked him to describe null physics briefly.</p>
<p><em>Null physics is a bottom-up theory built upon the solution to the ontological dilemma: why does the universe exist [instead of nothing]? The solution &#8211; that our universe is composed of nothing &#8211; leads directly to the four-dimensional geometry of which energy and space are composed. Null physics is the study and quantification of this geometry and its larger ramifications. In contrast to modern physics&#8217; top-down, heuristic approach, which uses measurements and mathematical symmetries to build models that conform to empirical reality, null physics derives empirical reality, such as the magnitude of unit elementary charge and the range and strength of the strong force, through calculations applied to the topology of a fully known underlying geometry.</em></p>
<p>I put it to Witt that because his theory is a blend of philosophy and science, that might be a double-edged sword?</p>
<p><em>Not at all. What we currently call physics originally began as natural philosophy. Physics replaced natural philosophy because it provided an accurate mathematical description of the macroscopic scale of the physical world. This set the stage for untold advances in engineering and technology, but many of the foundational questions that natural philosophy confronted, such as why the universe exists and why matter is composed of discrete particles, were lost in this transition, leaving us with empty mathematical models. Null physics is the best of both worlds, fusing a deep understanding of physical reality (as geometry) with empirical validation. The geometry used in Null physics is derived using logic and reasoning similar to that employed by natural philosophy, but has no philosophical component in its final geometric formulation.</em></p>
<p>Of course, there are other theories around that suggest the universe did not begin with the Big Bang, I asked Witt, what makes his stand out among them?  </p>
<p><em>Sweeping unification and empirical validation. Unlike other non-Big Bang theories, null cosmology is falsifiable, provides testable predictions, and gives a full accounting of the many nuanced properties of the intergalactic redshift and CMB. It also, unlike any cosmology before it (including the Big Bang), provides a logical reason for the universe’s existence and a clear framework that unifies a wide variety of known galactic properties with the large-scale universe. And in keeping with true scientific progress, the unification provided by null cosmology illuminates a number of currently unknown galactic properties, such as the vortical motion of a galaxy&#8217;s disk material.</em></p>
<p>Finally, I was still curious about the philosophical implications and asked about what this theory can tell us of our place in the universe.</p>
<p><em>It tells us everything about our place in the universe. It tells us why and how we exist on a finite scale that, because of space’s intrinsic symmetry, must exist precisely midway between infinite largeness and smallness. It tells us that the universe is, through causality and sheer size, large enough to contain its own history. In fact the universe must contain its own history, because each and every moment of our lives is integral to ultra-large-scale structure. Perhaps most importantly, null physics demonstrates that our existence is neither accident nor design &#8211; it is inevitable.</em></p>
<p>Convinced?</p>
<p>His theory has an additional redeeming feature for people hoping to eradicate the ultimate irrational explanation in that it closes the door on a designer. If the universe has <em>always</em> existed and always will exist, then how could a creator have any role to play at all? My cynical brain suspects that this could be one of the motives for the resurrection of the static universe theories that are springing up at regular intervals. Witt is not the first to try to defuse the Big Bang. In the final, and I use the word lightly, given that apparently there is no final, Witt&#8217;s conclusion could be summed up with the naive parent&#8217;s riposte to the childish question: Why are we here? Because we&#8217;re here!</p>
<div id="crp_related"><h3>Related Posts:</h3><ul><li><a href="http://www.sciencebase.com/science-blog/top-physics-discoveries-of-2006.html" rel="bookmark">Top Physics Discoveries of 2006</a></li><li><a href="http://www.sciencebase.com/science-blog/neutron-star-magnetic-field.html" rel="bookmark">Simulated Astronomical Magnetism</a></li><li><a href="http://www.sciencebase.com/science-blog/zen-and-the-art-of-global-maintenance.html" rel="bookmark">Zen and the Art of Global Maintenance</a></li></ul></div><p><a href="http://www.sciencebase.com/science-blog/discover-our-universe.html">How to Discover Our Universe</a> is a post from: <a href="http://www.sciencebase.com/science-blog">Sciencebase Science Blog</a></p>
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		<title>Alcohol Causes Cancer</title>
		<link>http://www.sciencebase.com/science-blog/alcohol-causes-cancer.html</link>
		<comments>http://www.sciencebase.com/science-blog/alcohol-causes-cancer.html#comments</comments>
		<pubDate>Wed, 18 Jun 2008 12:00:09 +0000</pubDate>
		<dc:creator>David Bradley</dc:creator>
				<category><![CDATA[Science]]></category>
		<category><![CDATA[spectroscopy]]></category>
		<category><![CDATA[alcohol]]></category>
		<category><![CDATA[medicine]]></category>

		<guid isPermaLink="false">http://www.sciencebase.com/science-blog/?p=1682</guid>
		<description><![CDATA[It&#8217;s quite illuminating that the following study has not yet reached the wider media. Without wishing to be too cynical, I do wonder whether that&#8217;s because the journal in which the work is published does not use a highly aggressive press office and marketing machine like so many other medical journals, which never seem to [...]<p><a href="http://www.sciencebase.com/science-blog/alcohol-causes-cancer.html">Alcohol Causes Cancer</a> is a post from: <a href="http://www.sciencebase.com/science-blog">Sciencebase Science Blog</a></p>
]]></description>
			<content:encoded><![CDATA[<p><a href="http://www.flickr.com/photos/sciencebase/" rel="nofollow"><img style="float:left;padding-right:4px;padding-top:5px;" src="http://www.sciencebase.com/science-blog/./images/wine-corks.jpg" alt="Wine corks (Photo by David Bradley)" /></a>It&#8217;s quite illuminating that the following study has not yet reached the wider media. Without wishing to be too cynical, I do wonder whether that&#8217;s because the journal in which the work is published does not use a highly aggressive press office and marketing machine like so many other medical journals, which never seem to be out of the news. The results in this paper are just as important and the implications perhaps even more far reaching than many other results that attract instantaneous (under embargo) media attention. Anyway, take a look and judge for yourself, oh and let me know afterwards if you think the headline for this post is way off mark.</p>
<p>Alcohol blamed for oral cancer risk &#8211; A large-scale statistical analysis of mouth and throat cancer incidence over a long period of time has looked at possible correlations between exposure to industrial chemicals, dust and alcoholic beverages in a wide variety of individuals in different occupations across Finland. The perhaps surprising conclusion drawn is that alcohol consumption rather than industrial chemicals or dusts is the critical factor associated with this form of cancer. Get the full story in this week&#8217;s edition of my SpectroscopyNOW column <a href="http://www.spectroscopynow.com/coi/cda/detail.cda?id=18848&#038;type=Feature&#038;chId=9&#038;page=1">here</a>.</p>
<p>I suppose it&#8217;s a little ironic that in the same edition of Spec Now, I&#8217;m also writing about how to make beer taste fresher and last longer on the shelf. NMR spectroscopy, and a chromatography sniff test have yielded results that could help brewers improve the flavour and shelf-life of beer thanks to work by scientists in Venezuela. The team has identified alpha-dicarbonyls as important compounds that reduce beer&#8217;s flavour and point to a new approach to brewing beer that stays fresher, longer. <a href="http://www.spectroscopynow.com/coi/cda/detail.cda?id=18846&#038;type=Feature&#038;chId=5&#038;page=1">Take a sip here&#8230;</a></p>
<p>Meanwhile, another subject of mixed messages regarding health benefits is that perennial favourite chocolate. To maintain the seductive and lustrous brown gloss of chocolate, so enticing to chocoholics the world over, food technologists must find a way to prevent fat bloom from forming on the surface and turning the surface an unappealing grey. Now, scientists from Canada and Sweden have found new clues to understanding the microstructure of chocolate and what happens when it turns grey with age. <a href="http://www.spectroscopynow.com/coi/cda/detail.cda?id=18847&#038;type=Feature&#038;chId=1&#038;page=1">More&#8230;</a></p>
<p>Finally, some straight chemistry with absolutely no hint of biomedicine, health, or pharmaceutical implications (yet). A novel structure studied using X-ray crystallography hints at the possibility of a carbon atom that, at first site seems to be a little different from the conventional textbook view. Could the oldest rule of organic chemistry have been broken at last, or is low atomic separation being equated too keenly with the presence of a bond, or could there be something else afoot, as Steve Bachrach suggests? <a href="http://www.spectroscopynow.com/coi/cda/detail.cda?id=18845&#038;type=Feature&#038;chId=8&#038;page=1">Read on&#8230;</a></p>
<div id="crp_related"><h3>Related Posts:</h3><ul><li><a href="http://www.sciencebase.com/science-blog/sniffer-e-coli-clues.html" rel="bookmark">Sniffer, E coli Clues, Graphene</a></li><li><a href="http://www.sciencebase.com/science-blog/bond-q-and-controlled-cleavage.html" rel="bookmark">Bond, Q, and Controlled Cleavage</a></li><li><a href="http://www.sciencebase.com/science-blog/alchemy-hydrogen-economics-and-toy-gun-crime.html" rel="bookmark">Alchemy, Hydrogen Economics, Lead-free Crime</a></li></ul></div><p><a href="http://www.sciencebase.com/science-blog/alcohol-causes-cancer.html">Alcohol Causes Cancer</a> is a post from: <a href="http://www.sciencebase.com/science-blog">Sciencebase Science Blog</a></p>
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		<title>Girly Games</title>
		<link>http://www.sciencebase.com/science-blog/girly-addiction-to-video-games.html</link>
		<comments>http://www.sciencebase.com/science-blog/girly-addiction-to-video-games.html#comments</comments>
		<pubDate>Wed, 05 Mar 2008 13:00:18 +0000</pubDate>
		<dc:creator>David Bradley</dc:creator>
				<category><![CDATA[Science]]></category>
		<category><![CDATA[spectroscopy]]></category>

		<guid isPermaLink="false">http://www.sciencebase.com/science-blog/girly-addiction-to-video-games.html</guid>
		<description><![CDATA[




My latest science news write-ups on the SpectroscopyNOW portal are now up for grabs. This week, I cover the apparent gender gap when it comes to computer games, how Japanese researchers are using near-infrared light to probe young women&#8217;s brains to find out if they can reduce stress and potentially acne with pleasant fragrances, and [...]<p><a href="http://www.sciencebase.com/science-blog/girly-addiction-to-video-games.html">Girly Games</a> is a post from: <a href="http://www.sciencebase.com/science-blog">Sciencebase Science Blog</a></p>
]]></description>
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<p>My latest science news write-ups on the SpectroscopyNOW portal are now up for grabs. This week, I cover the apparent gender gap when it comes to computer games, how Japanese researchers are using near-infrared light to probe young women&#8217;s brains to find out if they can reduce stress and potentially acne with <a href="http://www.spectroscopynow.com/coi/cda/detail.cda?id=18219&#038;type=Feature&#038;chId=3&#038;page=1" rel="nofollow">pleasant fragrances</a>, and the discovery that cancer cells seem to be stuffed full of the dreaded <a href="http://www.spectroscopynow.com/coi/cda/detail.cda?id=18219&#038;type=Feature&#038;chId=1&#038;page=1" rel="nofollow">trans fats</a>. You can find my other spec news from this week linked in the <a href="http://www.sciencebase.com/science-extra.html">Sciencebase Geeky Bits column</a>.</p>
<p><img style="float:left;padding-right:4px;padding-top:5px;" src='http://www.sciencebase.com/science-blog/./images/perfect-skin.jpg' alt='Perfect skin' />However, I want to step back a little with respect to that <a href="http://www.spectroscopynow.com/coi/cda/detail.cda?id=18209&#038;type=Feature&#038;chId=3&#038;page=1" rel="nofollow">video games research</a>. The team used the apparently powerful technique of functional MRI (basically a brain scan that can spot changes and lights up active regions of the brain). The researchers devised a very simple computer game, a kind of cross between Tetris and Pong (without the bats). To win you had to gain territory. The researchers scanned the brains of males and females while they played this game. Their results showed that men and women got the game, but the men were sharper when it came to realising you had to use a particular strategy to gain the most territory.</p>
<p>What was most interesting to Allan Reiss and colleagues at Stanford University School of Medicine who carried out the research was that the region of the brain associated with rewarding feelings lit up the most in the males than in the females. This, the researchers say, suggests a possible explanation as to why males enjoy, and even become addicted to, video games more commonly than females.  &#8220;These <span style="position:relative;color:white;width:200px;background:#05024F;border-width: 0px 0px 0px 0px;border-style: dotted;border-color: --;filter:alpha(opacity=25);-moz-opacity:.25;opacity:.25;float:right;padding: 0.2em; margin: 1em;font-family:Verdana,Arial, Helvetica,Georgia;font-size: 24px;line-height:26px; text-align: right;"><span style="filter:alpha(opacity=75);-moz-opacity:.75;opacity:.75;">gender </span><b> </b>differences <br><b></b>may <br><b>help </b>explain <br><b>why males </b>are <br><b>more </b>attracted <br><b>to, and </b>more <br><b>likely to become </b>&#8216;hooked&#8217; <br><b>on video games </b>than<span style="filter:alpha(opacity=90);-moz-opacity:.90;opacity:.90;"> females</span></span>gender differences may help explain why males are more attracted to, and more likely to become &#8216;hooked&#8217; on video games than females,&#8221; Reiss explains in the Journal of Psychiatric Research.</p>
<p>Now, I take issue with the fundamental assumption that Reiss and his colleagues make regarding video games. While historically video games have been aimed almost squarely at boys, the manufacturers over the last few years have recognised that they only corner half the potential market with such a biased aim. As such, they have developed dozens of new types of games that are not of the familiar war and killing fantasy type. They have also remodelled their hardware to offer colours and skins that will appeal to females, the pink and white Nintendos, for instance, generally appeal to the female market more than the blue.</p>
<p>More to the point though, my ten-year old daughter and dozens, if not all, of her friends have taken to Nintendos, Wiis, Playstations, Tamagotchi, just as addictively as their male counterparts, fighting for screen time on their various devices and computers. Admittedly, the games they play are more frequently of the SingStar, Petz, and Sims kind as opposed to Halo, World of Warcraft etc. They also network with each other online in various <span style="position:relative;color:white;width:200px;background:#05024F;border-width: 0px 0px 0px 0px;border-style: dotted;border-color: --;filter:alpha(opacity=25);-moz-opacity:.25;opacity:.25;float:right;padding: 0.2em; margin: 1em;font-family:Verdana,Arial, Helvetica,Georgia;font-size: 24px;line-height:26px; text-align: right;"><span style="filter:alpha(opacity=75);-moz-opacity:.75;opacity:.75;">online </span><b> games with small furry animals rather than </b>three-eyed<span style="filter:alpha(opacity=90);-moz-opacity:.90;opacity:.90;"> aliens</span></span>online games with small furry animals rather than three-eyed aliens with vast armaments. Like I say, though, they are just as addicted to these games as the boys.</p>
<p>So, while Reiss&#8217;s work is fascinating and does hint vaguely at latent aspects of how territorialism evolved in the male brain. One has to wonder whether if he and his colleagues created a different type of game, a more &#8220;feminine&#8221; type game, like a pet simulation, for instance, they would see those reward centres lighting up more brightly in the female brain. Perhaps if the experiment had had an intrinsic bias towards a feminine type of game and they&#8217;d seen such activity in their fMRI, they would have come to a very different conclusion about video game addiction.</p>
<div id="crp_related"><h3>Related Posts:</h3><ul><li><a href="http://www.sciencebase.com/science-blog/puberty-immunity.html" rel="bookmark">Pubic Immunity</a></li><li><a href="http://www.sciencebase.com/science-blog/fun-science-games.html" rel="bookmark">Fun Science Games</a></li><li><a href="http://www.sciencebase.com/science-blog/hacking-nightmare.html" rel="bookmark">Hacking Nightmare</a></li></ul></div><p><a href="http://www.sciencebase.com/science-blog/girly-addiction-to-video-games.html">Girly Games</a> is a post from: <a href="http://www.sciencebase.com/science-blog">Sciencebase Science Blog</a></p>
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		<title>Full Spectrum Science News</title>
		<link>http://www.sciencebase.com/science-blog/full-spectrum-science-news.html</link>
		<comments>http://www.sciencebase.com/science-blog/full-spectrum-science-news.html#comments</comments>
		<pubDate>Fri, 22 Feb 2008 13:00:08 +0000</pubDate>
		<dc:creator>David Bradley</dc:creator>
				<category><![CDATA[spectroscopy]]></category>

		<guid isPermaLink="false">http://www.sciencebase.com/science-blog/full-spectrum-science-news.html</guid>
		<description><![CDATA[
Musical molecules, bright fibres, polarised brain chemistry, and cholesterol regulation, all feature in my SpectroscopyNOW column this week.
Musical molecules &#8211; What do Schroedinger&#8217;s equation and Schoenberg&#8217;s expressionism have in common? Not a lot you might think. However, researchers in Germany and the US have now modelled the hydrogen molecule, the archetypal subject of molecular modelling, [...]<p><a href="http://www.sciencebase.com/science-blog/full-spectrum-science-news.html">Full Spectrum Science News</a> is a post from: <a href="http://www.sciencebase.com/science-blog">Sciencebase Science Blog</a></p>
]]></description>
			<content:encoded><![CDATA[<p><img style="float:left;padding-right:4px;padding-top:5px;" src='http://www.sciencebase.com/science-blog/./images/musical-molecules.jpg' alt='Musical molecules' /></p>
<p>Musical molecules, bright fibres, polarised brain chemistry, and cholesterol regulation, all feature in my SpectroscopyNOW column this week.</p>
<p><a href="http://www.spectroscopynow.com/coi/cda/detail.cda?id=18080&#038;type=Feature&#038;chId=9&#038;page=1">Musical molecules</a> &#8211; What do Schroedinger&#8217;s equation and Schoenberg&#8217;s expressionism have in common? Not a lot you might think. However, researchers in Germany and the US have now modelled the hydrogen molecule, the archetypal subject of molecular modelling, using a theory of behaviour that emerges from music. The study demonstrates how a hydrogen molecule responds to laser pulses as if the molecule&#8217;s vibrational motions, its quantum states, were the notes making up a changing musical chord and offers the opportunity of laser-controlled chemical reactions.</p>
<p><a href="http://www.spectroscopynow.com/coi/cda/detail.cda?id=18085&#038;type=Feature&#038;chId=1&#038;page=1">Fibre, fibre burning bright</a> &#8211; A European research team has developed novel strategies for the rapid trace element analysis of metals in polyamide synthetic fibres by graphite furnace atomic absorption spectrometry and inductively coupled plasma mass spectrometry. Their method allows the accurate determination for quality control of polyamide products containing titanium dioxide as an optical brightener.</p>
<p><a href="http://www.spectroscopynow.com/coi/cda/detail.cda?id=18090&#038;type=Feature&#038;chId=8&#038;page=1">Bad cholesterol regulator</a>  &#8211; US researchers have discovered exactly how a destructive protein binds to and interferes with one of the molecules involved in removing low-density lipoproteins (LDL), the so-called &#8220;bad&#8221; cholesterol, from the blood.</p>
<p><a href="http://www.spectroscopynow.com/coi/cda/detail.cda?id=18078&#038;type=Feature&#038;chId=5&#038;page=1">Bipolar disorder</a> &#8211; Spectroscopic studies of <em>post mortem</em> brain chemistry reveals that sufferers of bipolar disorder (often referred to as manic depression) have a distinct chemical signature linked to this mental illness. A collaboration between researchers in the UK and US also suggests a possible mode of action for the mood stabilisers used to treat the disorder and how they counteract changes in brain chemistry.</p>
<div id="crp_related"><h3>Related Posts:</h3><ul><li><a href="http://www.sciencebase.com/science-blog/bond-q-and-controlled-cleavage.html" rel="bookmark">Bond, Q, and Controlled Cleavage</a></li><li><a href="http://www.sciencebase.com/science-blog/stroke-guests-nir.html" rel="bookmark">Stroke, NIR, Guests</a></li><li><a href="http://www.sciencebase.com/science-blog/stinging-heavy-metal-resistance.html" rel="bookmark">Stinging Heavy Metal Resistance</a></li></ul></div><p><a href="http://www.sciencebase.com/science-blog/full-spectrum-science-news.html">Full Spectrum Science News</a> is a post from: <a href="http://www.sciencebase.com/science-blog">Sciencebase Science Blog</a></p>
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		<title>Composting Chitosan Cat-litter Composite</title>
		<link>http://www.sciencebase.com/science-blog/composting-chitosan-cat-litter-composite.html</link>
		<comments>http://www.sciencebase.com/science-blog/composting-chitosan-cat-litter-composite.html#comments</comments>
		<pubDate>Wed, 19 Dec 2007 16:00:40 +0000</pubDate>
		<dc:creator>David Bradley</dc:creator>
				<category><![CDATA[Science]]></category>
		<category><![CDATA[spectroscopy]]></category>

		<guid isPermaLink="false">http://www.sciencebase.com/science-blog/composting-chitosan-cat-litter-composite.html</guid>
		<description><![CDATA[
That has to be the oddest blog headline I&#8217;ve come up with this week, but it&#8217;s not in fact that esoteric once you get down to it. Basically, researchers in China have created a new material based on dolomite (porous kitty litter material) and the crab shell derivative chitosan.
The new composite material not only absorbs [...]<p><a href="http://www.sciencebase.com/science-blog/composting-chitosan-cat-litter-composite.html">Composting Chitosan Cat-litter Composite</a> is a post from: <a href="http://www.sciencebase.com/science-blog">Sciencebase Science Blog</a></p>
]]></description>
			<content:encoded><![CDATA[<p><a href="http://www.spectroscopynow.com/" rel="nofollow"><img style="float:left;width:120px;padding-right:4px;padding-top:5px;" src='http://www.sciencebase.com/science-blog/./images/spectroscopy-now.jpg' alt='Spectroscopy Now' /></a></p>
<p>That has to be the oddest blog headline I&#8217;ve come up with this week, but it&#8217;s not in fact that esoteric once you get down to it. Basically, researchers in China have created a new material based on dolomite (porous kitty litter material) and the crab shell derivative chitosan.</p>
<p>The new composite material not only absorbs water it can release an NPK (nitrogen, phosphorus, potassium) fertiliser over a prolonged period for use in agriculture and horticulture. Advantages are, improved irrigation efficiency and less run off into waterways together with improved crop yields. More on this, in my <a href="http://www.spectroscopynow.com/coi/cda/detail.cda?id=17716&#038;type=Feature&#038;chId=1&#038;page=1" rel="nofollow">SpectroscopyNOW column</a> this week and you get a chance to see a photo of my kitty too. What more could you want? Other than links to the rest of this week&#8217;s news in SpecNOW, of course.</p>
<p>In <a href="http://www.spectroscopynow.com/coi/cda/detail.cda?id=17742&#038;type=Feature&#038;chId=5&#038;page=1" rel="nofollow">NMR news</a>, a brainy approach to using microNMR coils could allow scientists to probe the activity of cerebral compounds, such as choline, without having to worry about NMR&#8217;s relatively low sensitivity. In the <a href="http://www.spectroscopynow.com/coi/cda/detail.cda?id=17733&#038;type=Feature&#038;chId=8&#038;page=1" rel="nofollow">X-ray ezine</a>, I report on how British scientists have demonstrated that it is possible to predict the crystal structures of small organic molecules using software, winning them accolades at this year&#8217;s Blind Test in Crystal Structure Prediction, organised by the University of Cambridge and hosted by the Cambridge Crystallographic Data Centre.</p>
<p>Finally, new <a href="http://www.spectroscopynow.com/coi/cda/detail.cda?id=17771&#038;type=Feature&#038;chId=9&#038;page=1" rel="nofollow">informatics evidence</a> suggests that the land-bridge which is currently the Bering Strait was the sole route into the Americas for humans tens of thousands of years.</p>
<div id="crp_related"><h3>Related Posts:</h3><ul><li><a href="http://www.sciencebase.com/science-blog/alchemy-hydrogen-economics-and-toy-gun-crime.html" rel="bookmark">Alchemy, Hydrogen Economics, Lead-free Crime</a></li><li><a href="http://www.sciencebase.com/science-blog/curious-x-shooter-antibiotics.html" rel="bookmark">Curious X-shooter Antibiotics</a></li><li><a href="http://www.sciencebase.com/science-blog/mighty-neat-diabetes-target.html" rel="bookmark">Mighty Neat Diabetes Target</a></li></ul></div><p><a href="http://www.sciencebase.com/science-blog/composting-chitosan-cat-litter-composite.html">Composting Chitosan Cat-litter Composite</a> is a post from: <a href="http://www.sciencebase.com/science-blog">Sciencebase Science Blog</a></p>
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		<title>Sweet Proteins, Crystallised Proteins</title>
		<link>http://www.sciencebase.com/science-blog/sweet-proteins-crystallised-proteins.html</link>
		<comments>http://www.sciencebase.com/science-blog/sweet-proteins-crystallised-proteins.html#comments</comments>
		<pubDate>Wed, 28 Nov 2007 16:00:06 +0000</pubDate>
		<dc:creator>David Bradley</dc:creator>
				<category><![CDATA[Science]]></category>
		<category><![CDATA[spectroscopy]]></category>

		<guid isPermaLink="false">http://www.sciencebase.com/science-blog/sweet-proteins-crystallised-proteins.html</guid>
		<description><![CDATA[
A new naturally derived artificial sweetener could soon hit the market, thanks to the development of a mass production technique devised by University of Wisconsin-Madison research Fariba Assadi-Porter. The sweetener, known as brazzein, is a 54 amino acid protein derived from an extract of the fruit of the tropical plant Pentadiplandra brazzeana Baillon. It has [...]<p><a href="http://www.sciencebase.com/science-blog/sweet-proteins-crystallised-proteins.html">Sweet Proteins, Crystallised Proteins</a> is a post from: <a href="http://www.sciencebase.com/science-blog">Sciencebase Science Blog</a></p>
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			<content:encoded><![CDATA[<p><img style="float:left;width:120px;padding-right:4px;padding-top:5px;" src="http://www.sciencebase.com/images/brazzein.jpg" alt="Brazzein sweet protein" /></p>
<p>A new naturally derived artificial sweetener could soon hit the market, thanks to the development of a mass production technique devised by University of Wisconsin-Madison research Fariba Assadi-Porter. The sweetener, known as brazzein, is a 54 amino acid protein derived from an extract of the fruit of the tropical plant <em>Pentadiplandra brazzeana</em> Baillon. It has been eaten in West Africa across the millennia, but only recently caught the attention of the West because of its incredible sweetness. The protein extract tastes sweet only to humans and old-world monkeys and is  is 2000 times sweeter than sucrose when compared to a 2% solution of sugar.</p>
<p>Assadi-Porter and her colleagues are using spectroscopy to help them understand the relationship between the structure of this protein and its sweetness. They have recently devised a new approach to fermenting it on a large scale and startup company Natur Research is now seeking FDA approval to commercialise the protein as a food stuff for the low-calorie drinks and food industries. A paper detailing the production process has now been accepted by <em>Protein Expression and Purification Journal</em>, and you can read more about the story in the <a href="http://www.spectroscopynow.com/coi/cda/detail.cda?id=17604&#038;type=Feature&#038;chId=3&#038;page=1">NMR channel on SpectroscopyNOW</a>.</p>
<p>More on proteins in this week&#8217;s issue: Roderick MacKinnon and his colleagues at Rockerfeller U have come up with a novel technique, lipid-detergent-mediated crystallization, that allows them to crystallise membrane proteins, such as the voltage-dependent potassium ion channel, in as near as natural state as possible. The approach could open the door to countless studies of membrane proteins using crystallography that have not previously been possible. More on that in the <a href="http://www.spectroscopynow.com/coi/cda/detail.cda?id=17607&#038;type=Feature&#038;chId=3&#038;page=1">SpectroscopyNOW X-ray ezine, here</a></p>
<p>Also in this week&#8217;s round up, news not related directly to proteins and molecular biology. Researchers in Canada and the US have used MRI to demonstrate that there is something like a three-year delay in the development of certain regions of the brain in children with ADHD. The most obvious delay is seen in the front cortex, a region important in thinking, concentration, and planning. Rather than worrying parents, the discovery should be reassuring to parents and sufferers, says Philip Shaw of the NIMH Child Psychiatry Branch who led the research because although there is a delay, brain development is otherwise normal. &#8220;Finding a normal pattern of cortex maturation, albeit delayed, in children with ADHD should be reassuring to families and could help to explain why many youth eventually seem to grow out of the disorder,&#8221; he says.</p>
<p>The research also revealed that the regions affected by the developmental delay are coincident with the regions that develop precociously in children with autism. More on the scan results, again in <a href="http://www.spectroscopynow.com/coi/cda/detail.cda?id=17600&#038;type=Feature&#038;chId=3&#038;page=1">SpectroscopyNOW</a>.</p>
<div id="crp_related"><h3>Related Posts:</h3><ul><li><a href="http://www.sciencebase.com/science-blog/expanding-proteins.html" rel="bookmark">Expanding proteins</a></li><li><a href="http://www.sciencebase.com/science-blog/mighty-neat-diabetes-target.html" rel="bookmark">Mighty Neat Diabetes Target</a></li><li><a href="http://www.sciencebase.com/science-blog/bond-q-and-controlled-cleavage.html" rel="bookmark">Bond, Q, and Controlled Cleavage</a></li></ul></div><p><a href="http://www.sciencebase.com/science-blog/sweet-proteins-crystallised-proteins.html">Sweet Proteins, Crystallised Proteins</a> is a post from: <a href="http://www.sciencebase.com/science-blog">Sciencebase Science Blog</a></p>
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		<title>Taking the P out of Urine Testing</title>
		<link>http://www.sciencebase.com/science-blog/taking-the-p-out-of-urine-testing.html</link>
		<comments>http://www.sciencebase.com/science-blog/taking-the-p-out-of-urine-testing.html#comments</comments>
		<pubDate>Fri, 16 Nov 2007 15:00:26 +0000</pubDate>
		<dc:creator>David Bradley</dc:creator>
				<category><![CDATA[Science]]></category>
		<category><![CDATA[spectroscopy]]></category>

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A new approach to testing urine samples without having to purify them first has led to the discovery of a new hormone that controls sodium excretion and so could be involved in controlling high blood pressure. Too much sodium equates to raised bp. The discovery solves a riddle that confronted medical scientists for more than [...]<p><a href="http://www.sciencebase.com/science-blog/taking-the-p-out-of-urine-testing.html">Taking the P out of Urine Testing</a> is a post from: <a href="http://www.sciencebase.com/science-blog">Sciencebase Science Blog</a></p>
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			<content:encoded><![CDATA[<p><img style="float:left;width:100px;padding-right:4px;padding-top:5px;" src="http://www.sciencebase.com/images/blood-pressure-hormone.jpg" alt="Blood pressure hormone" /></p>
<p>A new approach to testing urine samples without having to purify them first has led to the discovery of a new hormone that controls sodium excretion and so could be involved in controlling high blood pressure. Too much sodium equates to raised bp. The discovery solves a riddle that confronted medical scientists for more than four decades and could lead to new approaches to treating high blood pressure.</p>
<p>I asked team leader Frank Schroeder about the work and discuss it in detail in this week&#8217;s <a href="http://www.spectroscopynow.com/coi/cda/detail.cda?id=17560&#038;type=Feature&#038;chId=3&#038;page=1">SpectroscopyNOW</a>. One issue that must be addressed before such a discovery can be applied realistically to the develop of new therapies for high blood pressure, or even low blood pressure, is to find out whether the hormone is involved in other control systems in the body. This is somewhat likely given that most other known hormones multitask. I asked Schroeder about this aspect of the research:</p>
<p>&#8220;At this point, it is difficult to speculate about what other biological processes might be influenced by the newly identified compounds, and the next step will be to find the receptor(s) that the [hormonal] xanthurenic acid derivatives bind to,&#8221; he told me. &#8220;From our analyses, it appears that the two xanthurenic acid derivatives represent the actual signalling molecules &#8211; the activity is very well-defined and the compounds are of high specific potency. Furthermore, a closely related metabolite, xanthurenic acid itself, is not active.&#8221;</p>
<p>Also, in this week&#8217;s issue, in the field of atomic spectroscopy, Jordanian scientists have found that garlic extract can reduce the levels of the toxic heavy metals, cadmium and lead, in vital organs, such as the liver, heart, and kidneys. You can read more about that <a href="http://www.spectroscopynow.com/coi/cda/detail.cda?id=17567&#038;type=Feature&#038;chId=3&#038;page=1">here</a>.</p>
<p>In <a href="http://www.spectroscopynow.com/coi/cda/detail.cda?id=17553&#038;type=Feature&#038;chId=3&#038;page=1">pure chemistry</a>, it has been a record-breaking year for coordination chemists Klaus Theopold and Kevin Kreisel of the University of Delaware and their colleagues who have synthesised an organometallic chromium compound with the shortest Cr-Cr bond ever. Not since the 1978 work of F. Albert Cotton and his team at Texas A&#038;M University has such a short one been seen. Theopold told me that he does not think it will be too long before this new record is broken. &#8220;I don&#8217;t think it will be another 30 years, although I&#8217;d like to hold on to the record for a while,&#8221; he said, &#8220;As to who, there are three possibilities: somebody who is not trying for it, and discovers it accidentally (like us), Phil Power, or myself, because I am now interested and have some ideas.&#8221;</p>
<p>Finally, the rather delicate subject of <span style="position:relative;color:white;width:200px;background:#05024F;border-width: 0px 0px 0px 0px;border-style: dotted;border-color: --;filter:alpha(opacity=25);-moz-opacity:.25;opacity:.25;float:right;padding: 0.2em; margin: 1em;font-family:Verdana,Arial, Helvetica,Georgia;font-size: 24px;line-height:26px; text-align: right;"><span style="filter:alpha(opacity=75);-moz-opacity:.75;opacity:.75;">turning </span><b> </b>raw <br><b></b>sewage <br><b></b>into<span style="filter:alpha(opacity=90);-moz-opacity:.90;opacity:.90;"> compost</span></span>turning raw sewage into compost for farms. Remy Albrecht of the Paul Cézanne University in Aix-Marseille and colleagues have developed an <a href="http://www.spectroscopynow.com/coi/cda/detail.cda?id=17564&#038;type=Feature&#038;chId=3&#038;page=1">infra-red technique</a> that could be used to monitor how well the composting process is going for biological wastes, such as sewage sludge. Obviously, compost quality for land application must be monitored and controlled closely, but there are so many benefits, such as quickly raising nutrient levels and improving soil quality that it is worth the effort. An analytical approach to near infrared reflectance spectroscopy can provide an inexpensive way to monitor the composting process, Albrecht told me. </p>
<p>&#8220;NIRS is a highly reproducible technique able to draw a precise chemical fingerprint of an organic material Moreover, NIRS is rapid and makes it possible to analyse a large number of samples in a practical and timely manner. Control of maturation can be easily simplified with good calibrations and a data bank in reference,&#8221; he said.</p>
<p>I do worry about the accumulation of heavy metals from such biological sources as with each iteration from crop/livestock, to dinner table, to sewage plant, back to farm, they could increase in concentration. There is also the issue of pathogens. I&#8217;d be interested to learn what safeguards are in place to prevent their circulation.</p>
<div id="crp_related"><h3>Related Posts:</h3><ul><li><a href="http://www.sciencebase.com/science-blog/pre-eclampsia-nir-nano-dots.html" rel="bookmark">Pre-eclampsia, NIR, Nano-dots</a></li><li><a href="http://www.sciencebase.com/science-blog/a-tricorder-for-blood-disease-and-breast-cancer.html" rel="bookmark">A Tricorder for Blood Disease and Breast Cancer</a></li><li><a href="http://www.sciencebase.com/science-blog/spectral-science-news.html" rel="bookmark">Spectral Science News</a></li></ul></div><p><a href="http://www.sciencebase.com/science-blog/taking-the-p-out-of-urine-testing.html">Taking the P out of Urine Testing</a> is a post from: <a href="http://www.sciencebase.com/science-blog">Sciencebase Science Blog</a></p>
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