Comments on: Nitroglycerine and Sex http://www.sciencebase.com/science-blog/viagra-gel.html Science Blog from Freelance Science Writer David Bradley Thu, 09 Feb 2012 08:25:37 +0000 hourly 1 http://wordpress.org/?v=3.3.1 By: David Bradley http://www.sciencebase.com/science-blog/viagra-gel.html/comment-page-2#comment-637250 David Bradley Fri, 16 Jul 2010 13:56:31 +0000 http://www.sciencebase.com/science-blog/viagra-gel.html#comment-637250 @Ajog What an ignorant comment. As if not smoking and not drinking and looking after one's health were the only causes of ED. Ever heard of spinal injury? @Ajog What an ignorant comment. As if not smoking and not drinking and looking after one’s health were the only causes of ED. Ever heard of spinal injury?

]]> By: Ajog http://www.sciencebase.com/science-blog/viagra-gel.html/comment-page-2#comment-637249 Ajog Fri, 16 Jul 2010 13:02:14 +0000 http://www.sciencebase.com/science-blog/viagra-gel.html#comment-637249 Viagra! why? Why not just take care of their health? quit smoking and drinking! Viagra! why? Why not just take care of their health? quit smoking and drinking!

]]> By: Radon http://www.sciencebase.com/science-blog/viagra-gel.html/comment-page-2#comment-392488 Radon Mon, 14 Apr 2008 15:36:26 +0000 http://www.sciencebase.com/science-blog/viagra-gel.html#comment-392488 "Futura and GSK expect the new product codenamed MED2002, for some odd reason, to pass muster with the regulators in 2008 (so why didn’t they call it MED2008?) and be marketed soon thereafter as an over-the-counter, or maybe under-the-counter-in-a-brown-paper-bag, product." Here I agree, Radon “Futura and GSK expect the new product codenamed MED2002, for some odd reason, to pass muster with the regulators in 2008 (so why didn’t they call it MED2008?) and be marketed soon thereafter as an over-the-counter, or maybe under-the-counter-in-a-brown-paper-bag, product.”

Here I agree,

Radon

]]> By: David Bradley http://www.sciencebase.com/science-blog/viagra-gel.html/comment-page-2#comment-360788 David Bradley Fri, 14 Mar 2008 07:38:58 +0000 http://www.sciencebase.com/science-blog/viagra-gel.html#comment-360788 Dr Kiley (are you really an MD?). I'm not sure what point you're trying to make, this tongue-in-cheek blog post was simply reporting that this drug has entered another trial and pointing out that it not only offers several intriguing ironies, but should also provide spammers yet more fodder for their inane comments. By the way your spelling/typing in this comment is atrocious - vasodilaors? symtoms? eelderly? sexual <em>active</em>?) db Dr Kiley (are you really an MD?). I’m not sure what point you’re trying to make, this tongue-in-cheek blog post was simply reporting that this drug has entered another trial and pointing out that it not only offers several intriguing ironies, but should also provide spammers yet more fodder for their inane comments. By the way your spelling/typing in this comment is atrocious – vasodilaors? symtoms? eelderly? sexual active?)

db

]]> By: james kiley md http://www.sciencebase.com/science-blog/viagra-gel.html/comment-page-1#comment-360333 james kiley md Thu, 13 Mar 2008 18:01:37 +0000 http://www.sciencebase.com/science-blog/viagra-gel.html#comment-360333 Nitroglycerine sublingual tablets, being vasodilaors, do increase levels of nitric oxide. The drug is usually well tolerated. Amyl nitrate causes much more vasodilition and more profound symtoms such as increased heart rate, lower blood pressure etc. Nitroglcerine sublingual tablets have been used for decades by the eelderly population, with minimal side effects. Theroretically, this drug could be used during sexual active and should act similar to amyl nitrate, though it would be a less potent vasodilator. As a physician, I am quite familar with the tolerance of nitrogylcerine in most patients. Your thoughts on this? Nitroglycerine sublingual tablets, being vasodilaors, do increase levels of nitric oxide. The drug is usually well tolerated. Amyl nitrate causes much more vasodilition and more profound symtoms such as increased heart rate, lower blood pressure etc.
Nitroglcerine sublingual tablets have been used for decades by the eelderly population, with minimal side effects.
Theroretically, this drug could be used during sexual active and should act similar to amyl nitrate, though it would be a less potent vasodilator.
As a physician, I am quite familar with the tolerance of nitrogylcerine in most patients.
Your thoughts on this?

]]> By: sciencebase http://www.sciencebase.com/science-blog/viagra-gel.html/comment-page-1#comment-3674 sciencebase Fri, 14 Jul 2006 20:02:30 +0000 http://www.sciencebase.com/science-blog/viagra-gel.html#comment-3674 I know exactly what you mean Dan! I wasn't being picky about the chronology for the sake of it but just to let sciencebase readers know how long it is the NO story has been worked on and to allude to just how long it takes for such discoveries to filter through into the world of applications. You don't have a link for that ad on the web do you? Maybe I'll get my cartoonist friend Peter Welleman to rustle something up showing the transparency of pharmaceutical gels! I know exactly what you mean Dan! I wasn’t being picky about the chronology for the sake of it but just to let sciencebase readers know how long it is the NO story has been worked on and to allude to just how long it takes for such discoveries to filter through into the world of applications.

You don’t have a link for that ad on the web do you? Maybe I’ll get my cartoonist friend Peter Welleman to rustle something up showing the transparency of pharmaceutical gels!

]]> By: Dan Lednicer http://www.sciencebase.com/science-blog/viagra-gel.html/comment-page-1#comment-3671 Dan Lednicer Fri, 14 Jul 2006 18:01:24 +0000 http://www.sciencebase.com/science-blog/viagra-gel.html#comment-3671 The reference to a nitroglycerin gel brings to mind a rather graphic ad that ran in some German journal (Arzneimittel Forschung?) back some years ago. The ad depicted a man rubbing the gel on his chest presumably to treat angina. His chest was however quite transparent so that he seemed to be administering the gel directly to his heart! The term “some years ago” above is prompted by the age-induced error in the last posting…everything happened longer ago that one recalls. The reference to a nitroglycerin gel brings to mind a rather graphic ad that ran in some German journal (Arzneimittel Forschung?) back some years ago. The ad depicted a man rubbing the gel on his chest presumably to treat angina. His chest was however quite transparent so that he seemed to be administering the gel directly to his heart!

The term “some years ago” above is prompted by the age-induced error in the last posting…everything happened longer ago that one recalls.

]]> By: sciencebase http://www.sciencebase.com/science-blog/viagra-gel.html/comment-page-1#comment-3266 sciencebase Mon, 10 Jul 2006 10:09:57 +0000 http://www.sciencebase.com/science-blog/viagra-gel.html#comment-3266 Thanks for the comment Dan. It is of course the alkyl nitrites, rather than alkyl nitrates that are commonly used as "poppers" for enhanced sexual excitement. To quote from Wikipedia: "Physical effects include headache, flushing of the face, decrease in blood pressure, increase in pulse, dizziness and relaxation of involuntary muscles, especially the blood vessel walls and the anal sphincter." So, those headaches do seem to be common to the NO drugs. Incidentally, the discovery that nitric oxide (NO) is a signalling molecule with a vasodilatory and other roles was made in the 1980s and first announced publically by <a href="http://www.britannica.com/eb/article-9117800" rel="nofollow" rel="nofollow">Furchgott and Ignarro</a> <em>twenty</em> years ago in 1986 at a scientific meeting. Thanks for the comment Dan.

It is of course the alkyl nitrites, rather than alkyl nitrates that are commonly used as “poppers” for enhanced sexual excitement. To quote from Wikipedia: “Physical effects include headache, flushing of the face, decrease in blood pressure, increase in pulse, dizziness and relaxation of involuntary muscles, especially the blood vessel walls and the anal sphincter.” So, those headaches do seem to be common to the NO drugs.

Incidentally, the discovery that nitric oxide (NO) is a signalling molecule with a vasodilatory and other roles was made in the 1980s and first announced publically by Furchgott and Ignarro twenty years ago in 1986 at a scientific meeting.

]]> By: Dan Lednicer http://www.sciencebase.com/science-blog/viagra-gel.html/comment-page-1#comment-3201 Dan Lednicer Sat, 08 Jul 2006 17:25:47 +0000 http://www.sciencebase.com/science-blog/viagra-gel.html#comment-3201 For quite some time now, thrill seekers have inhaled amyl nitrate in order to enhance sexual excitement. This compound, like nitroglycerine or for that matter any of the "nitro" drugs for treating angina, acts via the release of NO. It was found about ten or so years ago that this very simple compound is released in the body and involved in a number of physiolgical responses. A number of direct acting vasodilators in fact act via NO. For quite some time now, thrill seekers have inhaled amyl nitrate in order to enhance sexual excitement. This compound, like nitroglycerine or for that matter any of the “nitro” drugs for treating angina, acts via the release of NO. It was found about ten or so years ago that this very simple compound is released in the body and involved in a number of physiolgical responses. A number of direct acting vasodilators in fact act via NO.

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