Regarding the assertion that vitamin D3 may inhibit immune response, the major modulators of immune response appear to be sugar http://www.communicationagents.com/sepp/2008/07/23/vitamin_a_and_d_synergy_and_balance.htm and Omega-6 fatty acids http://omega-6-omega-3-balance.omegaoptimize.com/.

The important question is not whether vitamin D3 supplementation is harmful or helpful but in what nutritional context is supplementation of benefit?

And as far as pathogens are concerned, the same sort of sugar/omega-6 oil laced diet that promotes an imbalance of gut flora may also set up an internal environment where vitamin D3 supplementation does more harm than good.

In my own personal experiment with vitamin D3 supplementation I am taking 5,000 IU this year. Last year the dose was 2,000 IU and I experienced one cold and one bout with influenza. In my younger years when I was not supplementing with anything I never developed flu symptoms and experienced a cold about once every five years.

I’m not sure what you mean.

Recently I started to take D3 at 10,000 per day or more based on current recommendations, then I found the Marshall Protocol and how they were actually curing people using pulsed low dose antibiotics, Benicar to activate the Vitamin D nuclear Receptors that are plugged up by D2 and L-Bacteria Biofilm defensive compounds. D3 then goes on to plug up the T cell receptors in ather parts of the immune system. Because of this well thought out information on presented by Amy Proal at Bacteriality.com I have suspended by vitamin D3 intake until I straighten all this out.

I wrote the following short essay on the Dr. Mercola facebook site. I have to say that to date Dr. Mercola has not answered any of my Q’s or concerns.

Okay, here is why, if you have an autoimmune disease, that you should avoid Steroidal D (D is not a Vitamin) otherwise known as D2 and D3. Pathogens produce binders that attach to VITAMIN D NUCLEAR RECEPTORS (VDR). D2 (25-D) does the same thing. Both of them block D3. This stops the D3 (1,25-D) from doing its job on the VDR. D3 now will seek other immune receptors like the T3 receptors and bind to them not allowing T3 to do its immune function. Taking massive amounts of D3 will only inhibit your ability to fight the pathogens and heal.

Okay. So now, you are worried so you go to your doctor and test for D. He/she will probably do a D2 (25-D) test and tell you that it is low. They’ll tell you that nick is full of it and prescribe that you should increase your vitamin D intake!!! Just one minute, now. Before you leave the doctor’s office insist that you have them do a D3 (1,25-D) test. It will probably come back as off the charts high.

Why is that, Nick? If you have an autoimmune disease, then the enzyme that is responsible for breaking down D3 (1,25-D), so that you don’t have too much D3, is suppressed. Also, the D3 has no VDR receptors to latch on to. D3 therefore goes on to block the rest of the immune system because D3 needs a home, too.

In conclusion, taking massive amounts of D3 in this case could entirely possibly shut down your entire immune system!!

Okay, then, so far so good, but what if you don’t have an autoimmune disease. How about this scenario, you take massive amount of D3 and you overwhelm the enzymes responsible for breaking down the excessive D3 in your system. The D3 will now have no choice, but to infect the rest of your immune system causing a self induced autoimmune disease response. If gone on unchecked, then the path is similarly bleak.

Okay, so Nick, then why is it that when I started to take D, that I felt better? I’m glad that you asked that question my good person. D2 and the Pathogens block the VDR Receptors and the massive amounts of D3 that you are taking are blocking the rest of the immune system. This allows the pathogens to grow and colonize unchecked by the immune system. However, the immune system when working properly causes a die-off of the pathogens. When the pathogens die, they give off toxic substances that cause all kinds of symptoms from mild to chronic. If the immune system can no longer kill them, then your symptoms magically disappear.

The kicker is that the pathogens continue on their merry way, year after year once the immune system is immobile. A portion of the pathogens do die just like everything else and this becomes a self sustaining toxic die-off. Chronic Fatigue Syndrome is the result.

Good Luck To All,
Nick D.