GERD’s dirty little secret

GERD’s dirty little secret – When omeprazole's patent expired AstraZeneca launched the optically pure version esomeprazole, which is apparently four times as active and gave them a new patent and a corner of the acid reflux market. Bizarrely, both forms of the drug (pro-drug in fact) are converted to the same chemical in the body and so you could get the same efficacy level as esomeprazole simply by taking more of the original omeprazole, which of course is now available as a much cheaper generic since the AZ patent expired. Another opportunity for NHS or health insurance savings?

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One thought on “GERD’s dirty little secret

  1. Chris Kresser, The Healthy Skeptic, wrote a series of articles on GERD that can be accessed here: http://thehealthyskeptic.org/what-everybody-ought-to-know-but-doesnt-about-heartburn-gerd

    Introductory remarks:

    “In this first article I will present evidence demonstrating that, contrary to popular belief, heartburn and GERD are caused by too little (not too much) stomach acid. In the second article I’ll explain exactly how low stomach acid causes heartburn, GERD and other digestive conditions. In the third article I’ll discuss the important roles stomach acid plays in maintaining health and preventing disease, and the danger long-term use of acid suppressing drugs presents. In the final article, I’ll present simple dietary and lifestyle changes that can eliminate heartburn and GERD once and for all.”

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