Lancet Calls for Open Access to TGN-1412 Trial Investigation

British medical journal, The Lancet, has called for an open and independent investigation of what went wrong with the small phase I clinical trial of TGN-1412 that had six men in intensive care within hours of the trial beginning.

“Commercial confidentiality should not obstruct independent scrutiny of the drug trial that led to six men becoming seriously ill in Northwick Park Hospital in London, UK,” states an Editorial in the Journal, “Both TeGenero and The Medicines and Healthcare products Regulatory Agency (MHRA) – who authorised the trial – denied The Lancet’s request to see the protocol stating that it is ‘commercially sensitive’.”

News has been terse to say the least since the initial media frenzy regarding the trial. Quite bizarrely, Northwick Park Hospital in north west London, is where eccentric UK medical comedy Green Wing is recorded.

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One thought on “Lancet Calls for Open Access to TGN-1412 Trial Investigation

  1. Two more of the men involved in the trial of TGN-1412 were released from hospital on March 31. Two remain in hospital. One is still in intensive care but is conscious, the other is said to be making good progress, according to the BBC.

    An additional report on April 1 described how one of the six men who became seriously ill during the trial told UK tabloids how he and the others are “furious” about the ordeal. He said that he could tell things were not going to plan before his turn for the injection came because of the immediate adverse effects on the others, and asks why did they carry on?

    More to the point, I’d ask why did he let them give him the injection if he saw the others react so badly?

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