Nov 14, 2006
Painkiller in saliva
A natural analgesic (painkiller) that is six times stronger than the opiate morphine has been found in human saliva.
In 2003, Catherine Rougeot and her colleagues at the Pasteur Institute identified a potent pain sensation inhibitor in rats they called sialorphin. The present work confirms the presence of a related compound in humans. The compound inhibits the same class of proteins as sialorphin.
The analgesic, termed opiorphin (someone not related to the research team registered domain name opiorphin.com yesterday!) is a peptide with the amino acid sequence: tyrosine glutamine arginine phenylalanine serine arginine.
In rat studies, injections of opiorphin suppressed pain sensation for both chemical-induced inflammation and acute physical pain. In both cases, the administered dose of 1 mg/kg opiorphin provided the same painkilling power as 3-6 mg/kg of morphine.
The authors hope to next identify which physiological conditions trigger the natural release of opiorphin, but also note that the strong analgesic properties of opiorphin warrants potential exploration for clinical pain management. However, Rougeot cautions that it might not be developable as a conventional painkiller as the compound may also have anti-depressant activity.
I’m curious though, if spit has this potent painkiller why does it hurt so much when you accidentally bite your tongue?
The work is reported in this week’s issue of PNAS.
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No offense taken Kayo. I do take your point that a lot of promising research gets mentioned in the press and then there is no subsequent follow up, but that’s been going of for years. Someone’s always got something to promote and journalists have always got space to fill. Moreover, who’s to know at the time of writing that any given discovery won’t become truly the next big thing?
Does this help explain why people put their fingers in their mouths when they get paper cuts?
April, doesn’t it depend where you get the papercut?