Red meat linked to increased risk of bowel cancer

The UK media today reported that red meat increases the risk of bowel cancer: e.g. Telegraph

35% increased risk screamed the headlines. But, as fascinating as the finding is none of the reports I saw mentioned the incidence rate and how low that actually is compared to, say, deaths from road accidents or obesity-related heart disease. No absolute risk was mentioned. If it’s 100 in a ten-thousand, then a 35% increase would then be 135 in 10000…

So, a 35% increased risk of something not very risky is not necessarily as significant as the cancer research organisations are claiming. Moreover, just one portion of any fish once a week can reduce the risk by 30%. So, presumably you can eat bacon, burgers and bangers 5 days a week and fish at weekends to almost cancel the positive effect with a negative.

Do you want Rosemary with that?

It’s not the most likely request you’ll hear at your local flame-grilled burger joint, but according to (KSU researchers, antioxidants in rosemary could help reduce the potentially harmful formation of heterocyclic amines during the “barbecuing” process. That’s all well and good, but who wants a burger tasting of rosemary, now if they could demonstrate the same benefits with onions, and a six-pack of beer, that would be a different matter.

Onion Skin

Many readers found my recent article in Reactive Reports (Picking up the sweat scent, issue 41) rather interesting, not least a 54-year old massage therapist from Houston, Texas, who emailed me to ask my advice on her body odour problem.

Apparently, she had only been working at her present fitness centre for a few months when she noticed the scent of her axillae (armpits to you and me) and arms had changed from the usual smell to an onion-like fragrance. She asked whether there were an enzyme available that might be taken orally to combat the bacteria producing this smell (no, enzymes are digested in the stomach, like other proteins), and whether or not she may have “picked up” the microbes in the health club.

It’s a possibility, I guess, especially as she is working in such close contact with clients.

Solutions? Using a pH balanced soap instead of shower gel? Switching deodorants? Maybe just wearing long sleeve tops 24/7 is the best option.

‘Asbo’ and ‘chav’ added to dictionary

I’m not sure exactly how many of the 1500 “new” words added to the Collins English Dictionary I will be splipping into my writing but here’s a selection so that readers can cross-check:

Adultescent
Asbo
Bouncebackability
Brand Nazi
Chav
Chavette
Chavish
Chavtastic
Exhibition killing
Ned
Property porn
Retrosexual
Skanger
Squeaky-burn time
Tapping up
Yarco

Old William must be turning in his grave, either that or jumping with glee at the idea that the language is just as dynamic today as it was in his time!

Genetic Orgasm

It’s no surprise that one of the most widely repeated news items this week is the finding that genetics is involved in a woman’s ability to achieve an orgasm: Google Search: orgasm genetics. But, does this give men a sexual get out clause? Probably not, the research suggests that couples may simply have to “work” harder. One thing that is missing from all the discussion in the news is how a particular gene package actually precludes orgasm. They talk about women who can orgasm through masturbation but not intercourse, and emphasise that environmental and psychological factors are also involved, but is it a brain chemistry effect (genetically speaking) or perhaps just a matter of anatomy?

Anyway, how would you like to have beaucoup des petit morts? Killer orgasms, in other words.

Fearing Fat, Airbag Atrocities

According to the June issue of Scientific American, a growing number of dissenting researchers are accusing the US government and medical authorities – as well as the media – of misleading the public about the health consequences of rising body weights. These researchers suggest that excess body weight may not be the serious health risk it is claimed (by others) to be.

As with the anti-antismoking lobby, there are always going to be dissenters in any argument concerning health and safety, who can cite examples of overweight smokers living healthy lives into their 90s. Anyway, if the fat and smoke don’t kill you, the airbag just might. At least according to a statistical analysis that is yet to be reported widely in the mainstream media.

Apparently, the National Highway Traffic Safety Administration (NHTSA) has reported that airbags saved some 10000 lives as of January 2004. But, statistician Mary Meyer of the University of Georgia, has carried out an analysis of the data to demonstrate that airbags actually increase the risk of death (when other factors are controlled for).

“NHTSA recorded 238 deaths due to airbags between 1990 and 2002, according to information about these deaths on their Web site,” said Meyer. “They all occurred at very low speeds, with injuries that could not have been caused by anything else. But is it reasonable to conclude that airbags cause death only at very low speeds? It seems more likely that they also cause deaths at high speeds, but these are attributed to the crash.

“For any given crash at high speed, we can’t know what would have happened if there had been no airbag; however, statistical models allow us to look at patterns in the data, and compare risks in populations, in a variety of situations.” The study was published this week in Chance (2005, 18(2), pp 3-16).

The new analysis directly contradicts earlier studies about the effectiveness of airbags, which have been required for drivers and front-seat passengers in all cars since the 1998 model year in the United States.

While the value of airbags seems dubious in the new study, the value of seatbelts is not. The analysis found that proper use of a seatbelt reduces the odds of death by 67 percent for any given speed category and airbag availability. Airbags, however, cause no statistical difference in car-crash deaths, except for unseatbelted occupants at low speeds, where the odds of death are estimated to be more than four times higher with an airbag than without.

It has been known for some time that airbags pose special risks to children and small women. Auto manuals routinely say young children, especially those in car seats, should not be put in front seats where they might be injured or killed by an inflating airbag.

The reason earlier studies have found that airbags save lives is that they used only a special subset of the available data, said Meyer. The Fatality Analysis and Reporting System (FARS) is a high-quality compilation of information about every highway accident for which a death occurred. The Crashworthiness Data System (CDS) is another high-quality dataset, containing random samples of all accidents. The previous studies used FARS, and Meyer’s study used CDS.

“When we look at the random sample of all accidents, we find that airbags are associated with increased risk of death,” she said, “and this increase is due to more deaths with airbags in low-speed crashes and no seatbelts. However, if we limit the dataset to include only collisions in which a fatality occurred, we get a significantly reduced risk of death due to airbags.”

By way of analogy, Meyer explained it this way: “If you look at people who have some types of cancer, you will see that those who get radiation treatment have a better chance of surviving than those who don’t. However, radiation is inherently dangerous and could actually cause cancer. If you give everyone radiation treatment, whether they have cancer or not, you will probably find an increased risk of death in the general population.

“Making everyone have airbags and then verifying the effectiveness using only fatal crashes in FARS is like making everyone get radiation and then estimating the lives saved by looking only at people who have cancer. Overall, there will be more deaths if everyone is given radiation, but in the cancer subset, radiation will be effective.”

The new study directly contradicts assertions about airbag safety on the NHTSA Web site, said Meyer. The correct analysis is important to obtain now, because in only a few years, there will be virtually no cars on the road without airbags.

“We are confident that our analyses better reflect the actual effectiveness of airbags in the general population [than earlier studies],” said Meyer. “The evidence shows that airbags do more harm than good.”

Emerging viral infections

Emerging viral infections: what did we learn from SARS?

This briefing document was prepared for the UK’s Royal Society in 2004, but its message seems just as relevant given the current warnings regarding avian flu and the allegedly imminent flu pandemic. Immediately after the Royal Society meeting, outbreaks of avian H5N1 disease were reported in a number of countries including Vietnam, Thailand, Laos, Cambodia, China, and Indonesia. Human cases had also been reported in Thailand, but the concern is whether human disease is been missed elsewhere. In 2005, this avian virus still poses a serious threat to human health and is one with significant implications for animal production and economies. The long-term, global implications are only just being considered. Should this incredibly virulent strain avian flu transcend the species barrier and become infectious between people we could be facing a disease far worse than SARS.

2020 UPDATE: We faced MERS after SARS and now COVID-19

Infectious threats

We are facing more and more emerging infections partly because of international travel and rising population densities, poverty, food and water insecurity, a refugee crisis, and continued interfacing between people and wildlife. Severe acute respiratory syndrome (SARS) in the winter of 2002-2003 was just a single example that has taught the international medical community, researchers, and policy makers lessons we must learn if we are to fight new, emergent infectious agents. Our hunter-gatherer ancestors were not afflicted with the likes of measles, mumps, and chicken pox. These diseases emerged as people moved more from place to place and populations rose. Environmental change too means the world has become the perfect culture medium for new pathogens.

We have, of course, benefited from two decades of disease research stimulated by HIV but we simply cannot predict the next new pathogen and must improve our understanding of spreading diseases if we are to face the next threat. Issues of preparedness, medical ethics, and civil liberties must be addressed urgently before the successor to SARS emerges.

Read David Bradley’s Report from Session 1: on how we can never conquer infectious diseases.