European Chemistry Congress

The very first European Chemistry Congress starts Sunday and runs till the end of the month. The event is being held in Budapest, Hungary, at Loránd Eötvös University, and promises to be an astounding affair showcasing chemical sciences in Europe and bringing together chemical and molecular scientists from industry, academia and government institutions across Europe and from around the world.

The conference has been organised by EuCheMS (European Association for Chemical and Molecular Sciences, formerly FECS) and is co-sponsored by GDCh, RSC and SFC with an old friend of mine, Professor Jean-Marie Lehn heading up the scientific committee.

It’s a long time since I wrote about the rise of European chemistry in a feature article for Science magazine (Science 18 June 1993 260: 1738-1739), and it seems that this conference has been a long time coming. But, like they say, better late than never.

ChemWeb Alchemist

In this week’s Alchemist news round up: oscillating carbon fibres could usurp silicon in the world of microscopic video, find out how a sugar molecule seen only on anthrax spores could help defeat the bacterium in the event of a bioterrorism attack. We also report on how the US government has asserted that levels of dioxins and related compounds have fallen in meat and poultry and we discover how to make see-through silver.

Finally, a new surfactant allows oil and water to be mixed and unmixed on demand and could mitigate oil spill disasters. Here’s the skinny: Canadian chemists have synthesised a new surfactant that allows oil and water to be mixed and de-mixed on demand depending on whether carbon dioxide or air is bubbled through the mixture.

Read more…

Science fair projects and experiments

With a new school year almost upon us, there is a pressing need for parents everywhere to get advance warning of the kind of science conundrums (conundra?) they will face when their little darlings return with that first batch of science homework.

As ever, sciencebase is here to help with a bench covered in science fair projects, a labful of science experiments and all the science books for home study you can bear.

A word of warning, please DO NOT try to light your last barbecue of the summer with liquid oxygen…

UB313 Xena

UB313

Astronomers working under the proverbial umbrella of the International Astronomical Union (IAU), have come up with a new definition of “planets” and smaller “solar system bodies” such as comets and asteroids, this week, but the definition is not without controversy.

If the definition is approved by the astronomers who are pointing their telescopes at each other at the IAU General Assembly in Prague, this week, then our Solar System will have 12 not nine planets, with more to come.

Our heavenly neighbours will be the eight classical planets that dominate the system, including Pluto, whose status hung in the balance for a while. But, there will be an additional three planets in the new burgeoning category of “plutons” described as Pluto-like objects — and Ceres. Pluto will at the time of writing remain a planet but be the prototype for the new category of “plutons.” Anything smaller than Pluto but with similar properties, presumably, will become a pluton rather than a planet.

With the advent of powerful new telescopes on the ground and in space, planetary astronomy has gone though an exciting development over the past decade. For thousands of years very little was known about the planets other than they were objects that moved in the sky with respect to the background of fixed stars. In fact the word “planet” comes from the Greek word for “wanderer”. But today hosts of newly discovered large objects in the outer regions of our Solar System present a challenge to our historically based definition of a “planet”.

The new definition accommodates the eight bodies from Mercury to Neptune and Pluto because they orbit a star and aare in “hydrostatic equilibrium,” which basically means they’re “almost round.”

Not everyone is happy with the new definition. Caltech’s Mike Brown co-discoverer of UB313 (aka Xena) is appalled by the notion that there could be many more than the “special” nine planets orbiting our sun. Estimates put the figure at 53 round objects are already known.

He told the Globe and Mail, that ‘To me, the word ‘planet’ always meant something special. Nine was special. Maybe 10. Fifty-three? No,…in some ways it drains the excitement of what I thought was an exciting find. Turns out it was the 12th planet. Who knew?’

Moreover, a counter definition that knocks Pluto off the list altogether is being mooted by rebel astronomers at the same meeting, according to New Scientist. This version tacks on the idea that to be a planet the object must be the dominant heavenly body in its orbital region. Unfortunately for Pluto, Neptune (not to mention Uranus) is much bigger and their orbits cross…so Pluto would, according to The Register, be planet-ish but not quite planetary.

Final voting will take place Thursday.

But, never mind the astronomers’ concerns, what are astrologers making of all this? Surely, their charts will all have to be redrawn if Xena is in the ascendent and Pluto on the decline! Maybe in the Age of Aquarius we shouldn’t be worrying about such trivia as planetary definitions and get back to solving other more pressing matters here on earth.

Generate molecular formula

Generate molecular formula

A rather common search on the sciencebase site seems to ask how to generate a molecular formula. Well, the method I use is to go straight to ChemSketch and fire up ACD/Dictionary, type in the name of the compound I want to produce and paste it into the ChemSketch window. That gives you the everyday 2D structure. A quick click of the “3D Viewer” button does what it promises to do and opens the molecule as a 3D view. At this point, it’s still flat and has to be optimised, so the “3D optimization” button is next. That renders the molecule as a three-dimensional molecular structure. Now, save as a mol file and as a ChemSketch structure.

Now, I follow one of several paths at this point depending on what use I am to put the molecular formula. If it’s to illustrate a scientific piece I’d often be simply using the 2D version. But, if I want something a bit flashier I’ll usually use the 3D view and tweak the settings to change background colour, add or remove hydrogen atoms, or re-render it as a space-filling or ball and stick molecule, depending on which format will best get across the chemical message.

Alternatively, I may shut ChemSketch altogether and re-open the mol file in Diamond from Crystal Impact, which can produce wonderful pseudo photographic quality molecular structures. And, if these aren’t good enough, the next step is to do a full 3D rendering in Pov-Ray, which provides scenic backgrounds, quasi-shadowing, and other wonderful effects to produce a beautifully metallic textured molecule hovering in space, for instance.

Science Movies

Science in the movies was the subject of a a feature I wrote for the now sunk HMSBeagle (on BioMedNet.com), but the world of cinema has moved on apace since then with dozens more feature films that are less science fiction than what my good buddy Carl Djerassi (well, I’ve met him twice!) refers to as science in fiction as well as more impressibley many that are purely science non-fiction.

Here’s just a list of a few currently available on DVD I’d recommend, they’re available on amazon of course but seem to be cheaper at a new site, “DVD ideas”, which has a whole section dedicated to movies about science. Thanks to the guys at DVD Ideas for alerting me to this.

Me & Isaac Newton –
$17.99 on Amazon, $13.99 on DVD ideas – Seven scientists explore the scientific ethos without getting tangled in the technical details of their important work. The film concentrates on how these scientists come up with their ideas and uncovers fascinating contrasts in their biographies and their thinking.

SolarMax – $19.99 on Amazon, $12.99 on DVD ideas – This mind-boggling presentation, originally presented in IMAX theaters, goes to great lengths to explore to far-reaching power and significance of our closest star. From ancient Earth to orbiting spacecraft, explore what the power of the sun means to humankind

Breaking Vegas – $21.99 on Amazon, $16.97 on DVD ideas – Based on Ben Mizrich’s bestselling book, Breaking Las Vegas tells the true story of six college students from MIT – including Mizrich himself – who used their math skills to win millions of dollars at Las Vegas casinos.

Theremin – $12.99 on Amazon, $9.89 on DVD ideas – A documentary about the inventor of one of the first electronic instruments, the eponymous theremin (the sound of which quickly became cliched in science fiction films as the accompaniment to shots of flying saucers as well as providing the eerie ooooooh-eeeeeh-ooooooh sounds in The Beach Boys’ Good Vibrations.

For All Mankind – $35.99 on Amazon, $29.96 on DVD ideas – Shot between December 1968 and November 1972, in the heyday of the space program, FOR ALL MANKIND tells the true story of the 24 men who travelled to the moon as the entire US, and indeed the rest of the world, watched in awe.

If you’re looking for science movies of a more technical or perhaps educational nature, then check out the Sciencebase science movies page. That page has various video links, as well as a few sample science clips.

Next stop, Chemistry Central

A new open access site for chemists – Chemistry Central – launches today as part of the newly announced Open Access Central group of sites from the makers of BioMedCentral.

CC collates peer-reviewed research from a range of open-access journals and makes available the original research articles as soon as they are published.

Deputy Publisher and former chemist Bryan Vickery explains the motivation, “We have seen increasing interest from chemists in the open access publishing model and, having launched two chemistry-specific titles in the last 18 months, the time seemed right for BioMed Central to create an open access publishing website to meet the needs of chemists,” he says.

On the CC roster are OA articles from Geochemical Transactions, the Beilstein Journal of Organic Chemistry, and chemistry-related articles from BMC Pharmacology, BMC Biochemistry, and BMC Chemical Biology.

As well as viewing the latest research highlights and content from featured journals, the Chemistry Central site provides a forum for the discussion of articles, and users can subscribe to email alerts.

“The BioMed Central team has created an open access publishing website to meet the needs of chemists,” Vickery told Sciencebase, he adds that, “The initial launch phase of Chemistry Central has three main thrusts. Firstly, to raise awareness among chemists that a credible open access alternative to traditional scholarly publications exists, that will disseminate their work more widely and increase readership and use. Secondly, it showcases the chemistry research which BioMed Central’s journals are already publishing, proving their technical suitability for chemistry research. Thirdly, by launching Chemistry Central we are offering our open access publishing services to those who wish to launch new open access journals in chemistry, or to transfer existing journals to this model.”

For a totally unrelated discussion forum check out this link where you can share your thoughts on almost anything, it seems, from news and sport to photos and music.

Plan B contraceptive

On Friday, August 18, Barr Laboratories asked the US Food and Drugs Administration to reconsider its application to make its Plan B contraceptive available over the counter. According to FierceBiotech’s John Carroll, “Given the FDA’s sudden willingness to work out a marketing plan for the contraceptive, Barr has a good shot at finally obtaining an approval that should have come through in 2004.” Carroll reckons that the FDA now has the opportunity to show the US that science and not ideology controls how therapeutics are reviewed. “Given the Bush administration’s clear preference for ideology,” Carroll says, “the FDA may have more difficulties ahead. But for now, there’s reason for hope.”

Plan B is an “emergency” contraceptive, backup birth control, in other words, a form of contraception often referred to as a morning after pill. It comes in the form of two levonorgestrel pills, which are taken orally after unprotected sex. Plan B reduces the risk of pregnancy. Those who oppose it on ideological grounds posit that it is tantamount to an abortion despite the fact that the timescale within which it must be used can be shorter than the time within which conception generally occurs.

More on Plan B from the FDA here. The FDA announced at the end of July that, “It is proceeding to work with [Barr] to resolve the remaining policy issues associated with the marketing of Plan B as an over-the-counter option.”

Will keep you posted on this or you can subscribe for free to FierceBiotech to get the low down.

Statins, heart attacks, and a protection racket

Structure of Simvastatin

Long-term treatment with statins help lower cholesterol and reduce heart attack and stroke incidence. But, it seems, GPs have not been prescribing enough as yet another benefit is now being touted in new research published today in the British Journal of Pharmacology. This latest study suggests this action only needs a few days of treatment, is independent of cholesterol lowering and helps the heart to recover following a heart attack.

Jing-Lin ZHAO and colleagues at the Fuwai Heart Hospital, Beijing, China, have demonstrate decreased ‘no-reflow’ and better preservation of ventricular function in animals treated for only two days with a statin called simvastatin (structure shown). They also identify the mechanism underlying this cardioprotective action, showing that the observed beneficial effects of simavastatin are abolished by blocking the KATP channel in mitochondria.

Following a heart attack, blood does not flow properly into vessels in the heart, even once they are re-opened. Increasing the blood flow in these vessels would decrease the area known as ‘no-reflow’ and restore more of the ventricular function. ZHAO’s results suggest that taking statins long-term not only reduces the likelihood of a heart attack, but could also give the heart a chance to recover from a heart attack by decreasing the damage done to heart muscle.

Of course, if those heart attack patients had been on statins in the first place…

The Loh down on corrosion

loh down science

Once more, a news story from the Sciencebase global offices features in Sandra Tsing Loh’s science news podcast out of Caltech. Click the little speaker icon, top left of this post to hear her voice.

“…there’s a new way to stop corrosion: Put it to SLEEP.

The secret, say Dmitry Shchukin of the Max Planck Institute in Germany and colleagues? A gel-like material embedded with nanoparticles .. tiny bits, billionths of a meter across, which house a chemical additive called benzotriazole.”