Spiderman v Geckoman

Forget Spiderman, Geckoman is where it’s at, at least so suggests research due to be published in the Journal of Physics: Condensed Matter. According to Nicola Pugno at the Polytechnic University of Turin, Italy, the secret of making a sticky, but non-stick, material could lie in creating a “hierarchical structure” of branching bristles from ever finer carbon nanotubes. Such a bristly material would mimic the physical properties of gecko feet that allow them to hang effortlessly by a single pad from even the smoothest of surfaces.

Pugno’s calculations suggest that the hierarchical approach could lead to a stiff, non-tangling material with tips flexible enough for temporary adhesion. Previously, the research team has suggested that carbon nanotubes might allow us to build a space elevator, which was blogged about at length in the summer of 2006.

According to a report in New Scientist, Stefano Mezzasalma of the University of Trieste in Italy says the approach definitely could work, “The first prototype of a Spiderman suit might be ready in a decade or so.” But, like I say, move over Spiderman, it’s Geckoman we want to see!

Welcome to Earth 2.0 (beta)

Earth 2.0No, before you switch off, this is not a Second Life clone, or anything to do with global wikis and blogs. This is the first astronomical post on Sciencebase for quite some time, but because it is not your usual run of the mill supernova announcement, or dark energy revelations, we thought it worthy of a slot. Okay, so what’s all the fuss?

Well, astronomers have finally discovered an Earth-like planet beyond the Solar System and it is bigger by half than earth. Most importantly, the exoplanet, spotted with the ESO 3.6 m telescope, by a team of Swiss, French and Portuguese scientists is capable of having liquid water. Could this Earth 2.0 offer human kind a planetary upgrade?

Well, it might be inhabitable, but the beta version has a few technical problems that might be difficult to overcome. First, aside from being 50% bigger than earth and therefore offering a lot of storage space, it also has a mass about five times that of the Earth, which means even the leanest among us will tip the scales. But, perhaps more importantly it orbits a red dwarf rather than a nice life-supporting star like the Sun. Of interest, but not necessarily a problem this planet has a couple of near neighbours, a Neptune-mass planet, and at least one more planet of about eight times the mass of the Earth.

More worrying, though the planet’s clock speed, or “year” is just 13 days and it is 14 times closer to the red dwarf than Earth is to the Sun. But, the exoplanet lies, nevertheless, in the life support zone in which water could be liquid.

“We have estimated that the mean temperature of this super-Earth lies between 0 and 40 degrees Celsius, and water would thus be liquid,” explains Stéphane Udry, from the Geneva Observatory, “Moreover, its radius should be only 1.5 times the Earth’s radius, and models predict that the planet should be either rocky — like our Earth — or covered with oceans,” he says.

Team member Xavier Delfosse from Grenoble University, France, has already marked this planet on his treasure map of the Universe, with an X. Of course, any pioneers hoping to boot up a new human race on exoplanet X, will have rather a long upload time, the host red dwarf, Gliese 581, is close to the Earth, lying at 20.5 light years in the constellation Libra. So, it will be a very long time before we have even the vaguest opportunity to get a closer look at Earth 2.0.

Chemical blogs, wikis, and quanta

I recently interviewed quantum chemist Steve Bachrach of Trinity University and asked him his thoughts on the web 2.0 revolution and whether or not chemists might benefit realistically from blogs and wikis.

“Well, this is really an issue of culture. My personal hesitancy to adopt Web 2.0 technologies is that I don’t have the time to read random thoughts by random individuals. I barely have time to keep up with the old-school (i.e., traditional journals) literature in my field. The blogosphere just seemed to me to be filled with the rantings of people who have nothing better to do with their time. Peter Murray-Rust’s blog was the first to demonstrate to me that real chemistry content could be had, that interesting and novel ideas could be found and shared and discussed.”

You can read the complete interview in the latest issue of Reactive Reports together with my regular round up of chemical science news for the site.

 Proteins’ Web of Intrigue  The latent strength of Miss Muffet’s arachnoid friend may have been in sexual allegory, but the image of a spider’s web as somehow weak, a glistening, gossamer netting for trapping only flies could not be further from the truth.

 Stem to Sperm  Stem cells from human bone marrow can be converted into early-stage sperm, according to a research team based at the North-east England Stem Cell Institute (NESCI), Newcastle.

 Dino Remains  We have not quite entered Jurassic Park, but researchers have successfully extracted protein from a 68 million year old Tyrannosaurus rex bone.

Chondroitin Fails Arthritis Test

ChondroitinWith Vioxx, Arcoxia, and potentially all COX2 inhibitors nixed, to what can sufferers of osteoarthritis turn? Many have sought relief in the supposedly natural ingredients of healthy joints – chondroitin and its agent glucosamine. However, there was scant evidence that taking these two compounds together had any benefits whatsoever beyond the anecdotal claims of some users convinced they worked.

Now, a team in Switzerland, where chondroitin is regularly prescribed as a health supplement, have demonstrated that the compound is no more effective in easing hip and knee pain in osteoarthritis than a placebo. Moreover, Peter Juni of the University of Berne suggests that its use should be discouraged.

Chondroitin sulfate is commonly taken as a health supplement because of a supposed association with the benefits in terms of joint “lubrication”. It is usually taken in combination with glucosamine because this compound allegedly acts as a carrier. However, there is no evidence that any individual is ever deficient in glucosamine and the benefits of supplementary chondriotin have not been proved. At best, results have been mixed.

The researchers at the University of Berne in Switzerland, conducted a meta review of data from 20 trials that included more than 3,600 patients with osteoarthritis and found that chondroitin apparently had no effect in relieving osteoarthritis. Details are published in the Annals of Internal Medicine.

Juni says there is no evidence which suggests that chondroitin helps decrease pain more than a placebo.

InChI=1/C13H21NO15S/c1-2(15)14-3-8(7(19)13(28-11(3)22)29-30(23,24)25)26-12-6(18)4(16)5(17)9(27-12)10(20)21/h3-9,11-13,16-19,22H,1H3,(H,14,15)(H,20,21)(H,23,24,25)/t3-,4+,5+,6-,7-,8-,9+,11-,12-,13-/m1/ s1/f/h14,20,23H

One burger could kill

Burger and friesGrandma always said, “Everything in moderation”, but then she always used to take her teeth out to eat soup, so what does she know? Apparently, even moderation can be dangerous, particularly when it comes to high fat food.

Tavis Campbell and colleagues at the University of Calgary have found that just one high-fat meal, a fast-food breakfast for instance, makes you prone to suffer the physical consequences of stress compared with someone eating a low-fat meal.

The team looked at the stress responses of two groups of students: fifteen students were fed a fatty breakfast meal (42 g fat) from a burger bar while the second group of fifteen got to dine on dry cereal with low-fat milk, cereal bars and non-fat yogurt (1 g fat). Both meals had the same number of calories and the low-fat breakfast included supplements to balance it for sodium and potassium, but the total fat content was very different.

Two hours later, the researchers carried out standard physical and mental stress tests and recorded the students’ cardiovascular responses. They performed a mathematical test designed to be stressful, completed a public speaking exercise about something emotionally provocative, held an arm in ice water, and had a blood pressure cuff inflated around an arm, which gradually causes a dull ache.

Regardless of the task, greater CV reactivity was seen in the high-fat group, including raised blood pressure, heart rate and blood vessel resistance. “What’s really shocking is that this is just one meal,” says Campbell.

“It’s been well documented that a high-fat diet leads to atherosclerosis and high blood pressure, and that exaggerated and prolonged cardiovascular responses to stress are associated with high blood pressure in the future,” he says, “So when we learn that even a single, high-fat meal can make you more reactive to stress, it’s cause for concern because it suggests a new and damaging way that a high-fat diet affects cardiovascular function.”

Thankfully, it is not all bad news. Campbell says more research is needed to fully understand how the mechanisms work. “Telling people to never eat something is probably not a good way to promote a better diet,” he says. “At the same time we do have an epidemic of obesity in North America and it’s important that people try to make informed choices.”

Science always hedges its bets in this way. If the argument were about whether to vote left or right, the politicians and lobbyists would make full-on assertions as to even the acute effects of a one-off high-fat vote. Yes, Campbell’s team has only carried out a small preliminary trial, and perhaps underfed and stressed students are not the best control group, but there findings do hint at yet another reason why we should side-step a high-fat diet.

The case is essentially closed on cigarettes in this sense, but individuals can make their own choice. Is it not about time, that the health message were made more forcefully. Maybe one burger is not going to kill you, but some people spend a fortune on finding ways to reduce stress and warding off the effects of aging, if even an occasional high-fat meal inverts all that effort, then perhaps it is time burgers carried a health warning too.

Details of the study are published today in the Journal of Nutrition, 2007, 137, 935-939

Cervical fluids and boron nitride

Two more reports of general interest from my SpectroscopyNOW column. The first is on a new informatics approach to understanding cervical vaginal fluids and the second on a new study of boron nitride the technological wonder material of the future
Screening for premature problems
The application of multiple protein identification algorithms to an analysis of cervical vaginal fluid (CVF) can provide a detailed map of biological markers to help researchers understand the course of human pregnancy and the problems that can arise. Preliminary tests suggest it could be used to determine the likelihood of a premature birth.

Inelastic boron nitride
The results of inelastic X-ray scattering and other techniques have been combined with ab initio calculations to characterise and explain the behaviour of the superficially simple binary material boron nitride. Insights from the research could lead to new ways to exploit the electronic and mechanical properties of hexagonal boron nitride.

Open Access Abbreviated, Combined

Phys Math CentralJust when you thought that the publishers had ran out of combinations of shortened discipline names – PhysChemOrgPhys, ChemCommPhysChem, CommPhysOrgGeoAstroChem (You know who you are!), BioMedCentral(!) is yet to launch another – PhysMath Central. PMC, an open access publishing platform, goes live today with a call for papers for its first journal is officially accepting papers for publication in its first journal, PMC Physics A, B, and C.

My former colleague on ChemWeb(!) Chris Leonard who is now heading up PMC tells me about why this endeavour is so important to the scientific community and publishing in general. “Global access to peer-reviewed research is as essential in the physical sciences as it is in the life sciences,” he says, “The same benefits apply, namely; increased readership, increased citations, decreased access barriers and the retention of copyright by the author.” Leonard is on record as saying that his move from the world of traditional publishing to the OA end of the spectrum represented an epiphany. “I started off at ChemWeb.com and subsequently moved to Amsterdam to work for Elsevier,” he explains, “I have now seen the light and am very happy to be developing physics and mathematics journals for the Open Access publisher BioMed Central.”

BMC explains the rationale behind the launch as being aimed at meeting the increasing demand for open access journals from major research institutes (such as CERN, the European Organization for Nuclear Research) and other funding organizations and government bodies. PhysMath Central could make research in physics, mathematics and computer science more widely available and increase access to this research to all institutes and individuals, without the burden of subscription charges. “The demand for open access is growing constantly as all scientists from all disciplines become aware of the benefits of open access publishing,” adds Leonard. Success will hinge, as with any new journal launch, on whether or not the putative authors feel the return on investment of submitting to the new journal will pay off in terms of readership and impact factor.

If the existence of yet more journals in the literature is not enough, PMC is also launching a blog, be sure to add it to your blogroll to keep up with developments and impact factor evolution. Oh, and one more thing, for their British authors: they deliberately missed off the “s” from “maths”.

Vioxx Follow-up Arcoxia Nixed

VioxxThe discovery of the life-threatening effects of Vioxx led to its rapid withdrawal by manufacturer Merck under pressure from drug agencies. Now, the successor to the notorious osteoarthritis drug, Arcoxia, is to be banned by the Food and Drug Administration.

Vioxx, a potent, yet purportedly selective, inhibitor of the inflammatory enzyme cyclooxygenase-2 (Cox-2) caused serious cardiovascular complications (heart attack, to put it bluntly) in too many patients once it was released to the wider prescribing world. Pharmaceutical giant Merck hoped that its Arcoxia follow-up in 2004 would fill the niche without being nixed. However doubts about the safety and potential side effects of all Cox-2 inhibitors in the eyes of the FDA has thrown the whole market into disarray.

The FDA’s report on the new drug suggested that its widespread use in treating arthritis could lead to 30,000 heart attacks each year. Merck’s counterargument suggested that the drug has a similar benefit-risk analysis profile as other drugs, such as diclofenac. FDA’s David Graham warned that Arcoxia could be “a potential public-health disaster” because of the increased risk of heart attack and stroke posed by long-term use of the drug. He suggested Arcoxia should be compared with its risk profile with naproxen, against which Vioxx had been compared originally and found wanting.

InChI=1/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3

Organic Kiwi Fruit

Organic kiwi fruitCould the claims of the “organic” farming movement be true after all? According to an international team who have analysed the antioxidant, mineral, and nitrate composition of kiwifruit, yes. Their findings published in the Journal of the Science of Food and Agriculture would suggest that growing the fuzzy green fruit using so-called organic principles leads to a higher content of health-promoting factors than those grown using conventional methods.

I asked team leader Adel Kader of the University of California, Davis, about his reasoning. “Most differences in composition between conventionally grown and organically grown fruits depend on differences in inputs,” he told us. These inputs include differences in fertilizers added and so results vary considerably from one study to the next, “In our kiwifruit study, the grower added more fertilizers to the organic kiwifruit plants than to the conventional ones and that is the reason for the higher mineral contents of the organic fruits,” he adds, “The one exception is phenolic [antioxidant] content, which has been shown in our study and in several other studies on a range of crops to be higher in organic than in conventional fruits.”

Kader believes that the difference is most likely due to the fruit having to survive against pests in the absence of synthetic pesticides. “Conventional agriculture practices utilize levels of pesticides that can result in a disruption of phenolic metabolites in the plant,” he says, “which have a protective role in plant defense mechanisms.” His hunch is further corroborated by the organic kiwifruit having thicker skins as well as the higher antioxidant activity which is thought to be a natural by-product of stress. He has a simple piece of advice for those dithering over whether to tuck into the fuzzy fruit: “My advice is that people eat more fruits regardless of whether they are conventionally or organically produced,” he told Sciencebase. More on this story in SpectroscopyNOW this week.

Large Hadron Collider at CERN

CERN magnetUPDATE: OCT 15, 2008 – Investigations at CERN* following a large helium leak into sector 3-4 of the Large Hadron Collider (LHC) tunnel have confirmed that cause of the incident was a faulty electrical connection between two of the accelerator’s magnets. This resulted in mechanical damage and release of helium from the magnet cold mass into the tunnel.

Proper safety procedures were in force, the safety systems performed as expected, and no one was put at risk. Sufficient spare components are in hand to ensure that the LHC is able to restart in 2009, and measures to prevent a similar incident in the future are being put in place.

‘This incident was unforeseen,’ said CERN Director General Robert Aymar, ‘but I am now confident that we can make the necessary repairs, ensure that a similar incident can not happen in the future and move forward to achieving our research objectives.’

UPDATE: SEPT 10, 2008 – The first particle beam has been sent around the 27km long tunnel at the LHC. This is the equivalent of a computer POST (power on, self test), they are yet to collide any hadrons at near light speed (that will be the BOOT proper). Sciencebase has now published its Large Hadron Collider LHC-FAQ and will keep you up to date with the latest from the LHC via the site’s RSS newsfeed; subscribe for free now to stay informed, alternatively, you can get updates by email. For concerns about black holes and revelations at the Large Hadron Collider, you may wish to read an extended guest post on the subject.

Physics followers among our readers will have no doubt seen the ubiquitous LHC “typo” a million times, so we’ve been very careful to avoid it in this item (email me if you cannot work out what it is). But, one thing that is not unavoidable, is the huge number of news reports that claim there was some kind of mathematical error that led to the recent little big bang at the CERN site.

Jonathan Leake at The Times, for instance, in an article headlined: “Big Bang at the atomic lab after scientists get their maths wrong” says, “A £2 billion project to answer some of the biggest mysteries of the universe has been delayed by months after scientists building it made basic errors in their mathematical calculations.”

Tests were started on the enormous magnets that will pull particles around the accelerator to great speeds in a giant experiment to mimic conditions at the beginning of time. But, I just heard from Fermilab visiting scientist Peter Limon, who is helping to commission the LHC, and he tells an entirely different story. What exactly was the cause of the accident deep underground at the CERN particle accelerator complex near Geneva in Switzerland?

“The problem with the inner triplet magnets in the LHC is as follows,” Limon told me, “The superconducting magnets themselves are in a pressure vessel (called the cold mass) that will eventually be cooled to 1.9 K for operation. These cold masses are suspended inside a cryostat (a vacuum vessel) so that they can be isolated from the heat that would otherwise make it impossible to cool the magnet. The suspension is made of a composite glass/epoxy material to minimize the heat flow from the outside of the vessel into the magnet.”

Some reports have claimed that the magnet was lifted out of its mountings. “The magnets did not lift itself off its mountings,” Limon said emphatically, “The break was in suspension pieces inside the cryostat. There was no motion of the magnet on its mountings, as far as we can tell.”

Limon then explained that, “Because of the geometry and the connections between magnets in the inner triplet, there is an unbalanced longitudinal force on the cold mass when the cold mass is pressurized.” This force, he adds, is transmitted from the cold mass to the the cryostat through the composite suspensions. “The design of the suspensions is inadequate to withstand those forces, but at 20 atmospheres, they broke,” he says, “The pressure test would have been successful if the pressure had gotten to 25 atm.”

Engineering calculations completed independently by Fermilab and CERN on March 28, the day after the accident, showed that the G-11 support structure in the magnets was inadequate to withstand the associated longitudinal forces. The word “inadequate” is rather euphemistic in this context, in reality the equipment simply was not up to the job in hand and it broke under the strain.

“In short,” Limon told me, “this was not a mathematical error, but an engineering omission. The full extent of the unbalanced longitudinal force (as much as 15 tons!) was not taken into account when the suspension was designed.”

I don’t believe design sabotage has been ruled out, but it is rather unlikely. Although the cynical among us will note that Fermilab who designed the magnet is also a scientific rival of CERN itself. Fermilab operates a particle accelerator, Tevatron, that is less powerful than the LHC but which Fermilab scientists are continually pushing to its limits. Moreover, they hope to beat CERN in the race to find the key particle that could unlock the secrets of the universe – the Higgs boson – before the LHC is even fired up.

The repair work by Fermilab and CERN staff, is according to the CERN website “being closely coordinated”. Fermilab personnel are on site at CERN, no doubt working under a cloud. That phrase “closely coordinated” would suggest some serious monitoring of activities. Too right.

Additionally, Fermilab is currently examining all aspects of the US-supplied components for the LHC just in case there are any other “potential vulnerabilities.” Whether CERN’s problems were mathematical or engineering in origin, CERN’s plans have been seriously delayed, which could give the Tevatron, with its dearth of “potential vulnerabilities” a particular advantage in the quest for the secrets of the universe.

NEWS FLASH

On Thursday 26 April, the last superconducting magnet of the Large Hadron Collider (LHC), a 15 metre long dipole weighing 34 tonnes, will be lowered in to the 27 km tunnel of the accelerator. With this magnet, the world’s largest superconducting installation receives its final component. The LHC is made up of some 1700 superconducting magnet assemblies, which will guide and focus the LHC’s particle beams. Teams are at work in the tunnel to conclude the complex task of magnet interconnection, and the sequence of procedures necessary before the machine’s scheduled start-up at the end of the year.

Coming soon: The Large Hadron Collider FAQ (the LHCFAQ) from Sciencebase.